Seroatlas · Human Serome Atlas

CCDC186

Coiled-coil domain-containing protein 186

Also known as: C10orf118, CC186_HUMAN, CCCP-1, FLJ10188, FLJ35301, golgin104

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3E2
Gene: CCDC186
Ensembl: ENSG00000165813
Chromosome: 10
Canonical length: 898 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to act upstream of or within insulin secretion involved in cellular response to glucose stimulus and response to bacterium. Predicted to be located in Golgi apparatus. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

898 residues, UniProt reviewed canonical sequence.

>Q7Z3E2|CCDC186
     1  MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD KTLCQPNEHN
    61  NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN FAKHISKTNE TEQKVTQILV
   121  ELRSSTFPES ANEKTYSESP YDTDCTKKFI SKIKSVSASE DLLEEIESEL LSTEFAEHRV
   181  PNGMNKGEHA LVLFEKCVQD KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR
   241  TETEKQHMNT IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK
   301  CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI KQLSQEKGRL
   361  HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK AEMDSHKETK DKLKETTTKL
   421  TQAKEEADQI RKNCQDMIKT YQESEEIKSN ELDAKLRVTK GELEKQMQEK SDQLEMHHAK
   481  IKELEDLKRT FKEGMDELRT LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV
   541  KTADQLQEQL QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA
   601  QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE EVQTLQAELA
   661  CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ ARRKLDQVES GSYDKEVSSM
   721  GSRSSSSGSL NARSSAEDRS PENTGSSVAV DNFPQVDKAM LIERIVRLQK AHARKNEKIE
   781  FMEDHIKQLV EEIRKKTKII QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA
   841  DNGLTLELSL EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC186 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 31 nTPM
pancreas: 20 nTPM
stomach: 16 nTPM
testis: 16 nTPM
small intestine: 15 nTPM
salivary gland: 15 nTPM

Single-cell type

esophageal apical cells: 410 nCPM
early spermatids: 273 nCPM
neutrophils: 260 nCPM
late spermatids: 235 nCPM
pdcs: 235 nCPM
breast lactating cells: 177 nCPM

Immune cell

plasmacytoid DC: 49 nTPM
basophil: 27 nTPM
neutrophil: 20 nTPM
eosinophil: 12 nTPM
gdT-cell: 8.7 nTPM
T-reg: 8.7 nTPM

Brain region

choroid plexus: 32 nTPM
cerebellum: 30 nTPM
hypothalamus: 25 nTPM
cerebral cortex: 23 nTPM
white matter: 21 nTPM
pons: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC186.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

10 conditions

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small GTPase binding

Cellular components

trans-Golgi network

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 186

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC186 as an antibody target. Whether an autoantibody or antibody against CCDC186 could matter depends on whether native CCDC186 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC186 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC186 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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