Seroatlas · Human Serome Atlas

CCDC185

Coiled-coil domain-containing protein 185

Also known as: C1orf65, CC185_HUMAN, FLJ35728

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N715
Gene: CCDC185
Ensembl: ENSG00000178395
Chromosome: 1
Canonical length: 623 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC185 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>Q8N715|CCDC185
     1  MAGFSHFSQP PYRDLWEPPR PGGERESTQR LGGQRSGADS TACSRAGTPG AESEAGACWL
    61  HPHCSFTPRP RRRGCSDSLR GSRSLSDVAR RPLERSRKHR PRSRRLEDAW GETGTKPRPA
   121  WQPQTQLPPQ RPQPCPHYPL AQGDSPPPCP GGAGTPLSGT FRVEKAQGGD QWAVPLGRHL
   181  GRWSPSSVPS ERSSVPSQKF KRHSACVCAQ KRDSSDQVES LASRDSQPLA SSKEMRSPHT
   241  QVLKSKLEEV VVSSQDQQIV ALVLTRLKKA QRIRELQQQA AKAWEELKRS DQKVQMTLER
   301  ERRLLLRQSQ EQWQEKEQRK TLQSPEQRGL RRDSQRKNVP PGESRWKEQP EDQESPRQEK
   361  LEKARAQAEH RKQCQVRRLR EQEKMLRNLR EQHSLQLQRR LVEACRKRHL HAVEGQKKVQ
   421  DTNLSSLINY QARKVLMDCQ AKAEELLRQL SLEQSFQRSQ EIHQGLRKER QRELREKAQK
   481  EEEQLQQARW RAGESEEQRK MRKRILVELA DEKIRQARSH VHKTTRDKVQ HLRELNHLRE
   541  KNHHILKLKA EKEEKCHIEG IKEAIKKKEQ RVQHISQGKD PNFQEFQKLP QASRREERAP
   601  PNSSLDQMVL EAQLRACQQN RGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC185 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 705 nCPM
late spermatids: 69 nCPM
late primary spermatocytes: 61 nCPM
leydig cells: 1.6 nCPM
peritubular myoid cells: 0.6 nCPM
early primary spermatocytes: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.9 nTPM
choroid plexus: 0.4 nTPM
amygdala: 0.3 nTPM
hippocampal formation: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC185 as an antibody target. Whether an autoantibody or antibody against CCDC185 could matter depends on whether native CCDC185 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC185 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC185 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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