Seroatlas · Human Serome Atlas

CCDC184

Coiled-coil domain-containing protein 184

Also known as: C12orf68, CC184_HUMAN, LOC387856

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q52MB2
Gene: CCDC184
Ensembl: ENSG00000177875
Chromosome: 12
Canonical length: 194 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q52MB2|CCDC184
     1  MEDGLLEIMT KDGGDMPAPL EVSTVPAVGD VISGEYNGGM KELMEHLKAQ LQALFEDVRA
    61  MRGALDEQAS HIQVLSDDVC ANQRAIVSMC QIMTTAPRQG GLGVVGGKGS FQSDPQEPET
   121  PSPGIGDSGL LGRDPEDEEE EEEEKEMPSP ATPSSHCERP ESPCAGLLGG DGPLVEPLDM
   181  PDITLLQLEG EASL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC184 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 32 nTPM
hypothalamus: 26 nTPM
cerebellum: 22 nTPM
midbrain: 14 nTPM
amygdala: 13 nTPM
hippocampal formation: 13 nTPM

Single-cell type

early spermatids: 70 nCPM
decidual stromal cells: 52 nCPM
granulosa cells: 41 nCPM
late primary spermatocytes: 38 nCPM
respiratory ciliated cells: 18 nCPM
late spermatids: 17 nCPM

Immune cell

memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 60 nTPM
pons: 57 nTPM
cerebral cortex: 50 nTPM
medulla oblongata: 35 nTPM
midbrain: 30 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4677
Domain of unknown function (DUF4677)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC184 as an antibody target. Whether an autoantibody or antibody against CCDC184 could matter depends on whether native CCDC184 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC184 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC184 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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