Seroatlas · Human Serome Atlas

CCDC183

Coiled-coil domain-containing protein 183

Also known as: bA216L13.7, CC183_HUMAN, KIAA1984, MGC15438

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T5S1
Gene
CCDC183
Ensembl
ENSG00000213213
Chromosome
9
Canonical length
534 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium tip,Cytosol,Mid piece

OverviewNCBI Gene

No narrative summary is available for CCDC183 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q5T5S1|CCDC183
     1  MRRHSETDVE EQTQELKTIT QLQEQCRALQ IQGVKENMDQ NKATLALLRS NIRRGAQDWA
    61  LAKKYDQWTI SKACGKNLPL RLAHCRSTME VVREKLRKYV FDRVNMHNLL IHLVRRRGQK
   121  LESMQLELDS LRSQPDASKE ELRLLQIIRQ LENNIEKTMI KIITSQNIHL LYLDLLDYLK
   181  TVLAGYPIEL DKLQNLVVNY CSELSDMKIM SQDAMMITDE VKRNMRQREA SFIEERRARE
   241  NRLNQQKKLI DKIHTKETSE KYRRGQMDLD FPSNLMSTET LKLRRKETST AEMEYQSGVT
   301  AVVEKVKSAV RCSHVWDITS RFLAQRNTEE NLELQMEDCE EWRVQLKALV KQLELEEAVL
   361  KFRQKPSSIS FKSVEKKMTD MLKEEEERLQ LAHSNMTKGQ ELLLTIQMGI DNLYVRLMGI
   421  NLPATQREVV LSNTLDLNSK LAYCEGKLTY LADRVQMVSR TEEGDTKVRD TLESSTLMEK
   481  YNTRISFENR EEDMIDTFQF PDMDHSYVPS RAEIKRQAQR LIEGKLKAAK KKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC183 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • testis: 23 nTPM
  • prostate: 1.8 nTPM
  • retina: 1.5 nTPM
  • thymus: 1.3 nTPM
  • ovary: 1.1 nTPM
  • parathyroid gland: 1.1 nTPM

Single-cell type

  • early spermatids: 189 nCPM
  • late spermatids: 166 nCPM
  • late primary spermatocytes: 85 nCPM
  • adrenal medulla cells: 11 nCPM
  • granulosa cells: 6.5 nCPM
  • pdcs: 5.8 nCPM

Immune cell

  • plasmacytoid DC: 1.4 nTPM
  • MAIT T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 5.2 nTPM
  • midbrain: 4.7 nTPM
  • cerebral cortex: 3.8 nTPM
  • pons: 3.8 nTPM
  • hypothalamus: 3.6 nTPM
  • medulla oblongata: 3.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC183.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 183

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC183 as an antibody target. Whether an autoantibody or antibody against CCDC183 could matter depends on whether native CCDC183 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC183 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC183 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC183. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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