Seroatlas · Human Serome Atlas

CCDC182

Coiled-coil domain-containing protein 182

Also known as: CC182_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NF36
Gene
CCDC182
Ensembl
ENSG00000166329
Chromosome
17
Canonical length
153 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in female gonad development. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>A6NF36|CCDC182
     1  MEPLYQAGSI LMTVNTLQGK KMIESGLQSG DFSLSQSWPS CLPPPADLEI LQQKVAGVQR
    61  ELEDFKKEAL KSIHYLEDAF CEMNGALVQQ EEQAARVRQR LREEEDRGIV RNKVLTFLLP
   121  REKQLREHCK RLEDLLLDRG RDALRATKKS QAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC182 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • testis: 27 nTPM
  • pancreas: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early spermatids: 258 nCPM
  • late spermatids: 234 nCPM
  • late primary spermatocytes: 158 nCPM
  • sertoli cells: 2.2 nCPM
  • early primary spermatocytes: 0.4 nCPM
  • undifferentiated spermatogonia: 0.4 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 0.6 nTPM
  • medulla oblongata: 0.4 nTPM
  • cerebral cortex: 0.3 nTPM
  • pons: 0.3 nTPM
  • spinal cord: 0.3 nTPM
  • hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0.7
gnomAD missense Z
0.81
DepMap mean gene effect
0.02
DepMap dependency class
none

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4715
  • Domain of unknown function (DUF4715)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC182 as an antibody target. Whether an autoantibody or antibody against CCDC182 could matter depends on whether native CCDC182 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC182 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC182 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC182. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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