Seroatlas · Human Serome Atlas

CCDC180

Coiled-coil domain-containing protein 180

Also known as: CC180_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1Z9
Gene: CCDC180
Canonical length: 1701 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC180 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1701 residues, UniProt reviewed canonical sequence.

>Q9P1Z9|CCDC180
     1  MRGGENRPPA RVQSSSEELE LRHQSLDAFP GRRLPGRGIQ PAAKMSSVGK VTQVPNGKAY
    61  QQIFQAEVQL VHSLAATRKR AAERSVTLKS GRIPMMKKVE TPEGEVMSPR QQKWMHSLPN
   121  DWIMENPVLH REKERAKREK ARESENTIAA REVRGLMDTI VPEKISTSTF QRQAEHKRKS
   181  YESALASFQE EIAQVGKEME PLIVDTGGLF LKKLTESDEE MNRLFLKVEN DTNLEDYTIQ
   241  ALLELWDKVA GRLLLRKQEI KELDEALHSL EFSRTDKLKS VLKKYAEVIE KTSYLMRPEV
   301  YRLINEEAMV MNYALLGNRK ALAQLFVNLM ESTLQQELDS RHRWQGLVDT WKALKKEALL
   361  QSFSEFMASE SIHTPPAVTK ELEVMLKTQN VLQQRRLKHL CTICDLLPPS YSKTQLTEWH
   421  SSLNSLNKEL DTYHVDCMMR IRLLYEKTWQ ECLMHVQNCK KQLLDWKAFT EEEAETLVNQ
   481  FFFQMVGALQ GKVEEDLELL DKSFETLADQ TEWQSSHLFK YFQEVVQLWE AHQSELLVQE
   541  LELEKRMEQH RQKHSLESQV QEAHLDRLLD QLRQQSDKET LAFHLEKVKD YLKNMKSRYE
   601  CFHTLLTKEV MEYPAIMLKE LNSYSSALSQ YFFVREIFEQ NLAGEVIFKF RQPEAHEKPS
   661  QKRVKKLRKK QGSKEDMTRS EESISSGTST ARSVEEVEEE NDQEMESFIT EEVLGQQKKS
   721  PLHAKMDESK EGSIQGLEEM QVEREGSLNP SLNEENVKGQ GEKKEESEEE DEKEEEEEEE
   781  KLEEEKEEKE AQEEQESLSV GEEEDKEEGL EEIYYEDMES FTISSGNTYF VFVPLEEEHC
   841  RKSHSTFSAM FINDTSSAKF IEQVTIPSRL ILEIKKQLRA GFFEHLEKWF DQCSLNTRVT
   901  VATKINELDS ELELHLHLHQ PRAQQIEKDI HNVRAAELLL HQEQLDSHCA GVTETLKKKR
   961  LMFCQFQEEQ NVRSKNFRLK IYDMEHIFLN ATRSQKLVTL SNTLHQELLS YVDVTQVSLR
  1021  SFRQYLEESL GKLRYSNIEF IKHCRLFSEG GNFSPKEINS LCSRLEKEAA RIELVESVIM
  1081  LNMEKLENEY LDQANDVINK FESKFHNLSV DLIFIEKIQR LLTNLQVKIK CQVAKSNSQT
  1141  NGLNFSLQQL QNKIKTCQES RGEKTTVTTE ELLSFVQTWK EKLSQRIQYL NCSLDRVSMT
  1201  ELVFTNTILK DQEEDSDILT SSEALEEEAK LDVVTPESFT QLSRVGKPLI EDPAVDVIRK
  1261  LLQLPNTKWP THHCDKDPSQ TGRGAWACGS RGSSEAGAGG AVCSPPVLCS CPGPSSPKGF
  1321  KRHRCQPENS GKKAVPSASA TSAGSFTPHP KPNKMERKYR VLGDKPPPAA EDFKGIILTL
  1381  LWESSENLLT VAEEFYRKEK RPVTRPDCMC DTFDQCAENI SKKILEYQSQ ANKYHNSCLI
  1441  ELRIQIRRFE ELLPQVCWLV MENFKEHHWK KFFTSVKEIR GQFEEQQKRL EKRKDKNAQK
  1501  LHLNLGHPVH FQEMESLHLS EEERQEELDS MIRMNKEKLE ECTRRNGQVF ITNLATFTEK
  1561  FLLQLDEVVT IDDVQVARME PPKQKLSMLI RRKLAGLSLK EESEKPLIER GSRKWPGIKP
  1621  TEVTIQNKIL LQPTSSISTT KTTLGHLAAV EARDAVYLKY LASFEEELKR IQDDCTSQIK
  1681  EAQRWKDSWK QSLHTIQGLY V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC180 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 13 nTPM
testis: 12 nTPM
fallopian tube: 6 nTPM
retina: 6 nTPM
cerebellum: 3.7 nTPM
epididymis: 1.9 nTPM

Single-cell type

podocytes: 26 nCPM
distal convoluted tubule cells: 22 nCPM
renal collecting duct intercalated cells: 21 nCPM
proximal tubule cells: 17 nCPM
renal connecting tubule cells: 14 nCPM
loop of henle epithelial cells: 13 nCPM

Immune cell

gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 28 nTPM
midbrain: 14 nTPM
medulla oblongata: 11 nTPM
cerebellum: 10 nTPM
spinal cord: 8.4 nTPM
cerebral cortex: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.09
DepMap dependency class: selective

OntologyGO

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4456
Domain of unknown function DUF4455
Domain of unknown function (DUF4455)
Domain of unknown function (DUF4456)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC180 as an antibody target. Whether an autoantibody or antibody against CCDC180 could matter depends on whether native CCDC180 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC180 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC180 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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