Seroatlas · Human Serome Atlas

CCDC18

Coiled-coil domain-containing protein 18

Also known as: CCD18_HUMAN, NY-SAR-41

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T9S5
Gene: CCDC18
Ensembl: ENSG00000122483
Chromosome: 1
Canonical length: 1454 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1454 residues, UniProt reviewed canonical sequence.

>Q5T9S5|CCDC18
     1  MESSSSDYYN KDNEEESLLA NVASLRHELK ITEWSLQSLG EELSSVSPSE NSDYAPNPSR
    61  SEKLILDVQP SHPGLLNYSP YENVCKISGS STDFQKKPRD KMFSSSAPVD QEIKSLREKL
   121  NKLRQQNACL VTQNHSLMTK FESIHFELTQ SRAKVSMLES AQQQAASVPI LEEQIINLEA
   181  EVSAQDKVLR EAENKLEQSQ KMVIEKEQSL QESKEECIKL KVDLLEQTKQ GKRAERQRNE
   241  ALYNAEELSK AFQQYKKKVA EKLEKVQAEE EILERNLTNC EKENKRLQER CGLYKSELEI
   301  LKEKLRQLKE ENNNGKEKLR IMAVKNSEVM AQLTESRQSI LKLESELENK DEILRDKFSL
   361  MNENRELKVR VAAQNERLDL CQQEIESSRV ELRSLEKIIS QLPLKRELFG FKSYLSKYQM
   421  SSFSNKEDRC IGCCEANKLV ISELRIKLAI KEAEIQKLHA NLTANQLSQS LITCNDSQES
   481  SKLSSLETEP VKLGGHQVES VKDQNQHTMN KQYEKERQRL VTGIEELRTK LIQIEAENSD
   541  LKVNMAHRTS QFQLIQEELL EKASNSSKLE SEMTKKCSQL LTLEKQLEEK IVAYSSIAAK
   601  NAELEQELME KNEKIRSLET NINTEHEKIC LAFEKAKKIH LEQHKEMEKQ IERLEAQLEK
   661  KDQQFKEQEK TMSMLQQDII CKQHHLESLD RLLTESKGEM KKENMKKDEA LKALQNQVSE
   721  ETIKVRQLDS ALEICKEELV LHLNQLEGNK EKFEKQLKKK SEEVYCLQKE LKIKNHSLQE
   781  TSEQNVILQH TLQQQQQMLQ QETIRNGELE DTQTKLEKQV SKLEQELQKQ RESSAEKLRK
   841  MEEKCESAAH EADLKRQKVI ELTGTARQVK IEMDQYKEEL SKMEKEIMHL KRDGENKAMH
   901  LSQLDMILDQ TKTELEKKTN AVKELEKLQH STETELTEAL QKREVLETEL QNAHGELKST
   961  LRQLQELRDV LQKAQLSLEE KYTTIKDLTA ELRECKMEIE DKKQELLEMD QALKERNWEL
  1021  KQRAAQVTHL DMTIREHRGE MEQKIIKLEG TLEKSELELK ECNKQIESLN DKLQNAKEQL
  1081  REKEFIMLQN EQEISQLKKE IERTQQRMKE MESVMKEQEQ YIATQYKEAI DLGQELRLTR
  1141  EQVQNSHTEL AEARHQQVQA QREIERLSSE LEDMKQLSKE KDAHGNHLAE ELGASKVREA
  1201  HLEARMQAEI KKLSAEVESL KEAYHMEMIS HQENHAKWKI SADSQKSSVQ QLNEQLEKAK
  1261  LELEEAQDTV SNLHQQVQDR NEVIEAANEA LLTKESELTR LQAKISGHEK AEDIKFLPAP
  1321  FTSPTEIMPD VQDPKFAKCF HTSFSKCTKL RRSISASDLT FKIHGDEDLS EELLQDLKKM
  1381  QLEQPSTLEE SHKNLTYTQP DSFKPLTYNL EADSSENNDF NTLSGMLRYI NKEVRLLKKS
  1441  SMQTGAGLNQ GENV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

testis: 7.6 nTPM
bone marrow: 6 nTPM
lymph node: 5.3 nTPM
thymus: 4.4 nTPM
tonsil: 4 nTPM
appendix: 2.9 nTPM

Single-cell type

epicardial cells: 434 nCPM
cardiomyocytes: 319 nCPM
early primary spermatocytes: 225 nCPM
adipocytes: 196 nCPM
monocyte progenitors: 165 nCPM
neutrophil progenitors: 154 nCPM

Immune cell

plasmacytoid DC: 9 nTPM
naive B-cell: 8.6 nTPM
memory B-cell: 8.3 nTPM
eosinophil: 4.5 nTPM
neutrophil: 3.3 nTPM
intermediate monocyte: 3 nTPM

Brain region

cerebellum: 3 nTPM
basal ganglia: 2.8 nTPM
midbrain: 2.8 nTPM
medulla oblongata: 2.7 nTPM
pons: 2.6 nTPM
amygdala: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.61

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of adipose tissue development

Cellular components

centriolar satellite

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC18 as an antibody target. Whether an autoantibody or antibody against CCDC18 could matter depends on whether native CCDC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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