Seroatlas · Human Serome Atlas

CCDC179

Coiled-coil domain-containing protein 179

Also known as: CC179_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BU77
Gene
CCDC179
Ensembl
ENSG00000255359
Chromosome
11
Canonical length
68 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC179 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>H3BU77|CCDC179
     1  MCLYCWDIEP SQVNPEGPRQ HHPSEVTERQ LANKRIQNMQ HLKKEKRRLN KRFSRPSPIP
    61  EPGLLWSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC179 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • testis: 26 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late spermatids: 2,728 nCPM
  • early spermatids: 1,465 nCPM
  • late primary spermatocytes: 48 nCPM
  • cardiomyocytes: 45 nCPM
  • epicardial cells: 16 nCPM
  • retinal ganglion cells: 7.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.8 nTPM
  • cerebral cortex: 0.5 nTPM
  • midbrain: 0.5 nTPM
  • hypothalamus: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM
  • pons: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0.01
gnomAD missense Z
0.39
DepMap mean gene effect
0.08
DepMap dependency class
selective

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC179 as an antibody target. Whether an autoantibody or antibody against CCDC179 could matter depends on whether native CCDC179 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC179 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC179 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC179. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...