Seroatlas · Human Serome Atlas

CCDC178

Coiled-coil domain-containing protein 178

Also known as: C18orf34, CC178_HUMAN, FLJ44050

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5BJE1
Gene: CCDC178
Ensembl: ENSG00000166960
Chromosome: 18
Canonical length: 867 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

867 residues, UniProt reviewed canonical sequence.

>Q5BJE1|CCDC178
     1  MTENKTVSSS STRDDQTNIG LTCQEVKALR EKAWSRTNEG NAMSQSLVLY GASKENSEGF
    61  HESKMTNTEG VNKGIYFSYP CRRHSCAVVN IPAPCVNKMI SHIQDVESKI QEHLKRFETS
   121  FEEWSRTSST KDLKEDWSVT TPVKEVKPGE KRDEKCPELK QEMETLLSEA IRLIKSLETD
   181  RADAEEALKQ QRSRKNMINM KIDSWSVWKL QELPLAVQKE HEAYLSDVIE LQWHLEDKAN
   241  QLQHFEKQKT ELEEANAKIQ ADIDYMNEHG PLLDSKQNQE LQDLKNHYKK KMEVMDLHRK
   301  VNEELEEALE ACENARLKAQ QIKEEIDKDI YQDEKTIEAY KREIYQLNSL FDHYSSSVIN
   361  VNTNIEEKEE EVTEAIRETK SSKNELHSLS KMLEDLRRVY DQLTWKQKSH ENQYLEAVND
   421  FYAAKKTWDI ELSDVAKDFS AISLACTKLT EDNKKLEIDI NKITVKTNES IRKKSKYESE
   481  IKYLTIMKLK NDKHLKNIYK EAYRIGTLFH LTKHKTDEME DKIAEVRRKF KGREEFLKKL
   541  TQGEVAAGMV LQKKLYSIYE VQALERKELI KNRAICAMSL AELQEPLLQL EDEAERIRSL
   601  DKEHSVMLNN IIDQKDLIRR KVGKVKKKLR KKGKKTLDAL IETESKRSAI FKDLEATKSK
   661  TMIFYAKINE LNEELKAKEE EKKSFDQTLE ILKNKFITMR FKREHAQTVF DHYMQEKKDC
   721  EERIFEEDQR FRVLLAVRQK TLQDTQKIIA DSLEENLRLA QEYQQLQITF LKEKDNYFNI
   781  YDKQLSLDTS IRDKKQLCQL QRRMHTLWQE HFKLVVLFSQ MRLANFQTDS QESIQKILAV
   841  QEESSNLMQH ILGFFQTLTD GTCENDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC178 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
adipose tissue: 10 nTPM
ovary: 9.4 nTPM
breast: 7.4 nTPM
spleen: 7.2 nTPM
kidney: 3.7 nTPM

Single-cell type

renal connecting tubule cells: 466 nCPM
distal convoluted tubule cells: 231 nCPM
loop of henle epithelial cells: 144 nCPM
late primary spermatocytes: 129 nCPM
late spermatids: 120 nCPM
corticotrophs: 85 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1.6 nTPM
medulla oblongata: 1.2 nTPM
choroid plexus: 1.1 nTPM
hypothalamus: 1.1 nTPM
spinal cord: 1.1 nTPM
basal ganglia: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.55
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 178

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC178 as an antibody target. Whether an autoantibody or antibody against CCDC178 could matter depends on whether native CCDC178 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC178 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC178 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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