Seroatlas · Human Serome Atlas

CCDC177

Coiled-coil domain-containing protein 177

Also known as: C14orf162, CC177_HUMAN, PLPL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQR7
Gene: CCDC177
Ensembl: ENSG00000267909
Chromosome: 14
Canonical length: 707 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC177 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

707 residues, UniProt reviewed canonical sequence.

>Q9NQR7|CCDC177
     1  MVDPVPEEEK AGAEPGDSGG DEAVASVPPD SQGAQEPAAS SASASASAAV PRKAEVPCAA
    61  AEGGRREQSP LLHLDLFNFD CPEAEGSRYV LTSPRSLEAC ARCAVKPVEL LPRALADLVR
   121  EAPGRSMRVA TGLYEAYEAE RRAKLQQCRA ERERIMREEK RRLFTPLSPA AAAAAAAAAA
   181  SAPSAGSSSS CSSASLPASP APRAARKASP SPSSARTQPP PAGSRTGRKS HSLDSLSRRR
   241  EGALSSESGA SSSSYSGESL RELRWPPRAS ARNSCPAGSA SSTTNAPGRP SALTLVPITG
   301  RSFSLGDLSH SPQTAQHVER IVRQVRAERG LRGVPERDRK IAALMLARHQ EELLLLEQRA
   361  AAHGQWELQR VHAKQRRERE EREKQRALEQ GRRAWAAQVE ERRGRRGREE REAARRRQRQ
   421  YERSEERRRE LAERQGLLRR ERAERAARED RLRKLQQEQN LKQREEGLQE GRERAEQIRR
   481  ERAQRAARAK QRQEGQLQRE KRELSRAERA RHEALLQGRT RQQRQEREGL RSSLEASLGR
   541  AQENYEHLVE QRTRELRERA RREELQGRRA KEAAERKERE HQAHLEALAR AGERRLQHAT
   601  QVAEEAVQQK ARRVGQSRLE KERAQRANKE KVERDEDCRR RELLQAIGRK LERSEQLTRE
   661  RRSALESARS TARASFHVRE KVREETNTRS FDRMVREAQL HASLDRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC177 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 4.3 nTPM
retina: 4.1 nTPM
cerebral cortex: 1.9 nTPM
hippocampal formation: 1.1 nTPM
amygdala: 0.9 nTPM
hypothalamus: 0.8 nTPM

Single-cell type

retinal bipolar cells: 11 nCPM
rod photoreceptor cells: 4.4 nCPM
retinal pigment epithelial cells: 4.3 nCPM
cone photoreceptor cells: 4.1 nCPM
ependymal cells: 3.5 nCPM
brain excitatory neurons: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 18 nTPM
cerebral cortex: 13 nTPM
hippocampal formation: 11 nTPM
basal ganglia: 8.8 nTPM
white matter: 8.8 nTPM
amygdala: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.15
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC177 as an antibody target. Whether an autoantibody or antibody against CCDC177 could matter depends on whether native CCDC177 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC177 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC177 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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