Seroatlas · Human Serome Atlas

CCDC175

Coiled-coil domain-containing protein 175

Also known as: C14orf38, CC175_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C221
Gene: CCDC175
Ensembl: ENSG00000151838
Chromosome: 14
Canonical length: 793 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC175 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

793 residues, UniProt reviewed canonical sequence.

>P0C221|CCDC175
     1  MALSPWTPGL GAGEKLVQAA AVSTGPSLEL CTLPSTLGSS VAVEALEQLF VVEQSLQSDY
    61  FKCNEEAKIF LKDIAVAVKK LEEMRKATID LLEIESMELN KLYYLLETLP NSIKRELEEC
   121  VRDARRLNLF EINTIKMRIT RTENEIELLK KKITDLTKYN EALGEKQEEL ARKHARFVLS
   181  LNQTMEKKAT TTVYINETYT KINLKREDIA LQKKCIQEAE ELMEKERAEY LIRKQELTAQ
   241  INEFENTREV KRMETYQKKK ELDKLQTKMS KIKETVTVSA AVLSDHNLEI ARLHESIRYW
   301  EQEVSELKKD LAILEAKLCF FTDNKEKLDD ISNDEKNEFL NKIKQLVETL HAARMEYKDL
   361  REKMKTLARQ YKIVLSEEEK AFLQKQKIHD ENQKQLTFIS QKEYFLSQKR VDIKNMEEGL
   421  ITLQELQQAT KTVYQQQIKI LSANLERESQ RCVITQWKMA CLRKKHARWT AKIKAEIQAI
   481  TEKIQNAEVR RIELLNETSF RQQEISGFVA QIEKLTTELK EEEKAFVNKE KMLMKELSKY
   541  EEIFVKETQI NKEKEEELVE YLPQLQVAEQ EYKEKRRKLE ELSNIITAQR QEEDLLNNHI
   601  FLFTRDFSRY ISNMEDVKQE LQQLRDQESK KNKDHFETLK NLENGFYIND QKADLLLLEN
   661  KKLKEYILYL KNNIEKYREG QEALMHTSSD LSRQLIAQEA QYKDLWAEFQ TTVKILVDNG
   721  EETLQDINNL TDKLRERDEK MQHVSTWLRG SLEGLRLLVE QESPMDLLKK KKHIRTRVHF
   781  PVVKCTEKNT LTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC175 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 4.1 nTPM
choroid plexus: 2.6 nTPM
testis: 2 nTPM
retina: 0.7 nTPM
pituitary gland: 0.4 nTPM
rectum: 0.3 nTPM

Single-cell type

ependymal cells: 188 nCPM
megakaryocyte progenitors: 183 nCPM
brain excitatory neurons: 90 nCPM
hematopoietic stem cells: 89 nCPM
choroid plexus epithelial cells: 88 nCPM
sertoli cells: 76 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 40 nTPM
choroid plexus: 8.7 nTPM
midbrain: 3.4 nTPM
medulla oblongata: 3.1 nTPM
pons: 2.8 nTPM
cerebral cortex: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.13
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 175

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC175 as an antibody target. Whether an autoantibody or antibody against CCDC175 could matter depends on whether native CCDC175 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC175 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC175 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...