Seroatlas · Human Serome Atlas

CCDC172

Coiled-coil domain-containing protein 172

Also known as: C10orf96, CC172_HUMAN, MGC35062

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7W6
Gene: CCDC172
Ensembl: ENSG00000182645
Chromosome: 10
Canonical length: 258 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in sperm midpiece. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>P0C7W6|CCDC172
     1  MSLESLFQHI IFTEHQAEES RRLMREVRSE ITRCREKIKK ATEELNEEKI KLESKVQQFF
    61  EKSFFLQLLK AHENALEKQY SEITNHRNML LQTFEAIKKQ MIEEEDKFIK EITDFNNDYE
   121  ITKKRELLMK ENVKIEISDL ENQANMLKSE MKSMEHDSSQ LNELQKQKSE LIQELFTLQR
   181  KLKVFEDEEN ESICTTKYLE AEKIKISEKP QNDTECLRLK KELELYKEDD MESVYEALQT
   241  EIEFLELTLA QKDLQESK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC172 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
retina: 2.9 nTPM
prostate: 0.9 nTPM
choroid plexus: 0.2 nTPM
adrenal gland: 0.1 nTPM
bone marrow: 0.1 nTPM

Single-cell type

early primary spermatocytes: 130 nCPM
late primary spermatocytes: 56 nCPM
rod photoreceptor cells: 30 nCPM
undifferentiated spermatogonia: 29 nCPM
early spermatids: 19 nCPM
differentiating spermatogonia: 5.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.3 nTPM
hypothalamus: 2.2 nTPM
cerebral cortex: 2.1 nTPM
medulla oblongata: 2 nTPM
cerebellum: 1.9 nTPM
basal ganglia: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 172

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC172 as an antibody target. Whether an autoantibody or antibody against CCDC172 could matter depends on whether native CCDC172 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC172 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC172 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...