Seroatlas · Human Serome Atlas

CCDC171

Coiled-coil domain-containing protein 171

Also known as: bA536D16.1, bA778P13.1, C9orf93, CC171_HUMAN, Em:AL513423.1, FLJ39267, FLJ46740

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6TFL3
Gene: CCDC171
Ensembl: ENSG00000164989
Chromosome: 9
Canonical length: 1326 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for CCDC171 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1326 residues, UniProt reviewed canonical sequence.

>Q6TFL3|CCDC171
     1  MNLNTSSNTG DTQRLKIASL DVKQILKNET ELDITDNLRK KLHWAKKEKL EITTKHNAEL
    61  ASYESQIAKL RSEVEKGEAL RQSLEYDLAV ARKEAGLGRR AAEERLAEAH RIQEKLCAQN
   121  SELQAKTNET EKAFQTSQQK WKEECRRFEH DLEERDNMIQ NCNREYDLLM KEKSRLEKTL
   181  QEALEKHQRE KNEMESHIRE TALEEFRLQE EQWEAERREL QFIVQEQDTA VQNMHKKVEK
   241  LETEHMDCSD LLRRQTSELE FSTQREERLR KEFEATTLRV RKLEENIEAE RAAHLESKFN
   301  SEIIQLRIRD LEGALQVEKA SQAEAVADLE IIKNEFKEVE SAYEREKHNA QESFAKLNLL
   361  EKEYFSKNKK LNEDIEEQKK VIIDLSKRLQ YNEKSCSELQ EELVMAKKHQ AFLVETCENN
   421  VKELESILDS FTVSGQWTSG IHKDKDKPPS FSVVLERLRR TLTDYQNKLE DASNEEKACN
   481  ELDSTKQKID SHTKNIKELQ DKLADVNKEL SHLHTKCADR EALISTLKVE LQNVLHCWEK
   541  EKAQAAQSES ELQKLSQAFH KDAEEKLTFL HTLYQHLVAG CVLIKQPEGM LDKFSWSELC
   601  AVLQENVDAL IADLNRANEK IRHLEYICKN KSDTMRELQQ TQEDTFTKVA EQIKAQESCW
   661  HRQKKELELQ YSELFLEVQK RAQKFQEIAE KNMEKLNHIE KSHEQLVLEN SHFKKLLSQT
   721  QREQMSLLAA CALMAGALYP LYSRSCALST QRDFLQEQVN TFELFKLEIR TLAQALSTVE
   781  EKKQEEAKMK KKTFKGLIRI FRKGVIAVLA ANRLKILGQS CASLFTWMES FKEGIGMLVC
   841  TGEPQDKHKF PKHQKEQLRC LQALSWLTSS DLLAAIISSM AELQDVIGKA DPNSRICGHL
   901  LIGAAKNSFA KLMDKISLVM ECIPLHSSRS ITYVEKDSLV QRLAHGLHKV NTLALKYGLR
   961  GHVPITKSTA SLQKQILGFT QRLHAAEVER RSLRLEVTEF KRSVNEMKKE LDKAQGLQMQ
  1021  LNEFKQSKLI THEKFESACE ELNNALLREE QAQMLLNEQA QQLQELNYKL ELHSSEEADK
  1081  NQTLGEAVKS LSEAKMELRR KDQSLRQLNR HLTQLEQDKR RLEENIHDAE SALRMAAKDK
  1141  ECVANHMRAV ENTLHKVRDQ ISLSWSAASR NDFTLQLPKL HLETFAMEGL KGGPEVVACQ
  1201  AMIKSFMDVY QLASTRIMTL EKEMTSHRSH IAALKSELHT ACLRENASLQ SIGSRDHSNL
  1261  SIPSRAPLPA DTTGIGDFLP LKAELDTTYT FLKETFINTV PHALTSSHSS PVTMSANANR
  1321  PTQIGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC171 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
endometrium: 5.4 nTPM
retina: 5 nTPM
thymus: 4.5 nTPM
smooth muscle: 3.1 nTPM
cerebellum: 2.3 nTPM

Single-cell type

hematopoietic stem cells: 329 nCPM
early primary spermatocytes: 234 nCPM
late primary spermatocytes: 225 nCPM
late spermatids: 223 nCPM
ependymal cells: 209 nCPM
respiratory deuterosomal cells: 200 nCPM

Immune cell

basophil: 2.4 nTPM
naive B-cell: 0.6 nTPM
MAIT T-cell: 0.5 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

cerebellum: 21 nTPM
cerebral cortex: 20 nTPM
white matter: 19 nTPM
basal ganglia: 18 nTPM
amygdala: 18 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: -3.32
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 171

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC171 as an antibody target. Whether an autoantibody or antibody against CCDC171 could matter depends on whether native CCDC171 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC171 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC171 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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