Seroatlas · Human Serome Atlas

CCDC170

Coiled-coil domain-containing protein 170

Also known as: bA282P11.1, C6orf97, CC170_HUMAN, FLJ23305

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYT3
Gene
CCDC170
Ensembl
ENSG00000120262
Chromosome
6
Canonical length
715 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cell Junctions

OverviewNCBI Gene

The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q8IYT3|CCDC170
     1  MSLDCTSHIA LGAASPAPEE TYDHLSEVPV TREQLNHYRN VAQNARSELA ATLVKFECAQ
    61  SELQDLRSKM LSKEVSCQEL KAEMESYKEN NARKSSLLTS LRDRVQELEE ESAALSTSKI
   121  RTEITAHAAI KENQELKKKV VELNEKLQKC SKENEENKKQ VSKNCRKHEE FLTQLRDCLD
   181  PDERNDKASD EDLILKLRDL RKENEFVKGQ IVILEETINV HEMEAKASRE TIMRLASEVN
   241  REQKKAASCT EEKEKLNQDL LSAVEAKEAL EREVKIFQER LLAGQQVWDA SKQEVSLLKK
   301  SSSELEKSLK ASQDAVTTSQ SQYFSFREKI AALLRGRLSM TGSTEDTILE KIREMDSREE
   361  SRDRMVSQLE AQISELVEQL GKESGFHQKA LQRAQKAENM LETLQGQLTH LEAELVSGGV
   421  LRDNLNFEKQ KYLKFLDQLS QKMKLDQMAA ELGFDMRLDV VLARTEQLVR LESNAVIENK
   481  TIAHNLQRKL KTQKERLESK ELHMSLLRQK IAQLEEEKQA RTALVVERDN AHLTIRNLQK
   541  KVERLQKELN TCRDLHTELK AKLADTNELK IKTLEQTKAI EDLNKSRDQL EKMKEKAEKK
   601  LMSVKSELDT TEHEAKENKE RARNMIEVVT SEMKTLKKSL EEAEKREKQL ADFREVVSQM
   661  LGLNVTSLAL PDYEIIKCLE RLVHSHQHHF VTCACLKDVT TGQERHPQGH LQLLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC170 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 31 nTPM
  • choroid plexus: 11 nTPM
  • ovary: 6.3 nTPM
  • thyroid gland: 5.2 nTPM
  • adrenal gland: 3.9 nTPM
  • lung: 3.9 nTPM

Single-cell type

  • respiratory ciliated cells: 815 nCPM
  • fallopian tube ciliated cells: 672 nCPM
  • epididymal efferent duct ciliated cells: 570 nCPM
  • ependymal cells: 428 nCPM
  • endometrial ciliated cells: 333 nCPM
  • choroid plexus epithelial cells: 228 nCPM

Immune cell

  • eosinophil: 6.2 nTPM
  • intermediate monocyte: 2.8 nTPM
  • non-classical monocyte: 2.8 nTPM
  • classical monocyte: 2.1 nTPM
  • neutrophil: 1.8 nTPM
  • myeloid DC: 1.2 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • midbrain: 11 nTPM
  • medulla oblongata: 8.3 nTPM
  • spinal cord: 7.2 nTPM
  • white matter: 6 nTPM
  • hypothalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 170-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC170 as an antibody target. Whether an autoantibody or antibody against CCDC170 could matter depends on whether native CCDC170 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC170 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC170 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC170. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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