Seroatlas · Human Serome Atlas

CCDC17

Coiled-coil domain-containing protein 17

Also known as: CCD17_HUMAN, FLJ33084

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LX7
Gene: CCDC17
Ensembl: ENSG00000159588
Chromosome: 1
Canonical length: 622 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q96LX7|CCDC17
     1  MDSHSGEPAL LPCGTCDMVF RSSALLATHT QRFCIGHPTQ EMTFGAQASV ATEPQRAAVV
    61  PQEHQGVPQE PQGLPDQQAS RSALKRLTEE VQWLRLSLQE MRPWITEVPR VFAGPWTRSE
   121  ARPQSPMSEA VGSPSERLRA LFRTRARRVA EMEAQSRALQ LRGEELSRRL QVVACTRGGM
   181  SRLFGLEQEI RELQAEAGRT RGALEVLGAR IQELQAEPGN PLSSRREAEL YSPVQKANPG
   241  TLAAEIRALR EAYIRDGGRD PGVLGQIWQL QVEASALELQ RSQTRRGRAG ATSGELPVVE
   301  AENRRLEAEI LALQMQRGRA PLGPQDLRLL GDASLQPKGR RDPPLLPPPV APPLPPLPGF
   361  SEPQLPGTMT RNLGLDSHFL LPTSDMLGPA PYDPGAGLVI FYDFLRGLEA SWIWVQLRTG
   421  LARDGRDTGR TTALPPALCL PPPPAPGPMG NCAILASRQP VPRLPPSSSV SLVCELQVWQ
   481  GLAWARAPQP KAWVSLGLFD QDQRVLSGRW RLPLRALPLD PSLSLGQLNG IPQAGQAELF
   541  LRLVNARDAA VQTLAEINPA SVHEYQYPPP VSSTSSLEAS FLTPAVGFAD PPPRTEEPLS
   601  GVKDRDEGLG PHHSSDLPPV SF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 34 nTPM
lung: 3.9 nTPM
cervix: 1.1 nTPM
bone marrow: 0.4 nTPM
choroid plexus: 0.3 nTPM
basal ganglia: 0.2 nTPM

Single-cell type

fallopian tube ciliated cells: 206 nCPM
respiratory ciliated cells: 202 nCPM
epididymal efferent duct ciliated cells: 129 nCPM
endometrial ciliated cells: 97 nCPM
ependymal cells: 16 nCPM
neutrophils: 7.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1.9 nTPM
medulla oblongata: 1.2 nTPM
pons: 0.4 nTPM
cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 1.14
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 17

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC17 as an antibody target. Whether an autoantibody or antibody against CCDC17 could matter depends on whether native CCDC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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