CCDC169
Coiled-coil domain-containing protein 169
Also known as: C13orf38, CC169_HUMAN, LOC728591, RP11-251J8.1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NNP5
- Gene
- CCDC169
- Ensembl
- ENSG00000242715
- Chromosome
- 13
- Canonical length
- 214 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear speckles,Vesicles
OverviewNCBI Gene
No narrative summary is available for CCDC169 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
214 residues, UniProt reviewed canonical sequence.
>A6NNP5|CCDC169
1 MKEERNYNFD GVSTNRLKQQ LLEEVRKKDA VQLSIFELRH KITELEAKLN TDNEGSEWKT
61 RYETQLELND ELEKQIVYLK EKVEKIHGNS SDRLSSIRVY ERMPVESLNT LLKQLEEEKK
121 TLESQVKYYA LKLEQESKAY QKINNERRTY LAEMSQGSGL HQVSKRQQVD QLPRMQENLV
181 KTGRYNPAKQ KTVSAKRGPV KKITRPNHLP ELHPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCDC169 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 56 nTPM
Expression across tissuesHPA
Tissue
- testis: 56 nTPM
- bone marrow: 2.7 nTPM
- epididymis: 2.3 nTPM
- retina: 2.3 nTPM
- parathyroid gland: 1.8 nTPM
- smooth muscle: 1.4 nTPM
Single-cell type
- late spermatids: 2,737 nCPM
- early spermatids: 700 nCPM
- late primary spermatocytes: 321 nCPM
- bergmann glia: 25 nCPM
- choroid plexus epithelial cells: 20 nCPM
- early primary spermatocytes: 12 nCPM
Immune cell
- basophil: 0.2 nTPM
- neutrophil: 0.2 nTPM
- naive B-cell: 0.1 nTPM
- NK-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 22 nTPM
- white matter: 21 nTPM
- cerebellum: 21 nTPM
- basal ganglia: 19 nTPM
- amygdala: 17 nTPM
- hippocampal formation: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.33
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4600
- Domain of unknown function (DUF4600)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCDC169 as an antibody target. Whether an autoantibody or antibody against CCDC169 could matter depends on whether native CCDC169 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCDC169 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCDC169 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...