Seroatlas · Human Serome Atlas

CCDC168

Leucine-rich repeat transmembrane protein CCDC168

Also known as: C13orf40, CC168_HUMAN, FLJ40176

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDH2
Gene: CCDC168
Ensembl: ENSG00000175820
Chromosome: 13
Canonical length: 7081 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

7081 residues, UniProt reviewed canonical sequence.

>Q8NDH2|CCDC168
     1  MSKQYYSFKK GVGSGLEDNT FMTLWDFLES WIIQNDWVAI FFIILLGIIF EIILMKACAS
    61  FWKKPTLPEK GSSDVQETED SCPKSRKLAP ENWSVINSSS GERVGTFLEK RITSSLTSEE
   121  KECNFEDRIL FSREILWSGT SESEDQVSPS SESHVPSSNG ISSSLPLFYS EVEETCLSHT
   181  EHPDREYETI QFSSKKLFSM MKTNKNKNSG FSSDLSFSAS RFTVENEDLD VAPCPLAHLF
   241  LSRDQVRLLE ENVRNQIPSK PKTKLGSRTT YQCSRSQESL NQNQPSVGMV ISVQAQDSFP
   301  GQNAFQNQGL YEVQFTSQAQ YINHNQESIK SQPESKASNF AQPEDVMKKP FSSSTQDSFQ
   361  SQDLDRNQHF VEVPSIVEAK YSVKGLESDE HLGEDQHCVW FIDSNKVKYS IKGQDTIFKN
   421  AEFLVLTLNP NLVTEDMPQL RSVKAQGQQQ IVSSELNQDS VYSSVPLLST IKGQKNRRKT
   481  PDSKSKLSLN VPSLKAKKTP TSQVFQITVC HTLKNRNELG CKNNTEKKEL HERKDISDIA
   541  LHLISVSKLI LPYVKNYSRK QLVKVMPGLI KCGHFLQKQN KSPDTEKINY AGPLEETGIS
   601  DITKKEKEYD KENKRLKNIS PKMLPQLEQS FMVNTVQLKA PCLLVETNGK SKESLKDSIT
   661  QAKGIGITEF HVLNSKKPFD LHIPKHKTSL EEAISKPMQK LVSSPEMESN NRMKIQEDLQ
   721  SSENSHLQLS NGEELPTSTP KTQRCFPREN TQKQKDFLEL VLELSNVGLL ISPGSKMHKS
   781  SEELEAIKIQ VNTESVNLKE SKPLILNVTE DSDLRESEEL ECNTGSNITN MHQDKETSDA
   841  FHSATYTTIS QLPDTETHSI SKAKADTLRI IRLSHSASKQ EKLPDEKETQ NAEYIDKSCT
   901  FKKPQQCDRK EQEKEANSEL TQGFRFSIHL KQKPKYVKFQ MEQISSGSSK APNKEQEVQP
   961  QTLSTQTILE NSPCPMMDPF QVEKVKQSTD RPTDRESAGD PKNPLTMPEN LPVGELLIET
  1021  TEYSVPFGGN LQKTTDSHIA EEKEDVKRYL PAVALGSFNN HLLTLPYFKR QEIKKKLSET
  1081  KSVLSVKYVI MKVKKPAISL MPYINICGTS NHRKKMGGNF EIIIKQILQD KIAAGMLLNV
  1141  IYPPMSILPN TRMYSRLNAE NHSHIKLVQE ESQIEREEKY PYFINEGNES QNTLDAKLQD
  1201  EVKGVKETLP KAVLHDSCNL GLDAHLEKEI KTEKEMHQPI PFTETIIESV VSPIMELSHA
  1261  ENVKSTQKTQ TDCKCTADSE TPSPISGKSL IGDPLNQTRE SYIPSNGSDT REMGYCFAEE
  1321  KTEIPKDLPA TSPETFNYCT PVLSCSKVMK KRVTFALTTS TAKPKCVNTK AVKPSISETV
  1381  SVTSHRKKSE LDFKTKFKKI NQTKGLVPEC LNTLCSPMHS RLQREFCLPA SQLKQGETAD
  1441  KTYTDVFAKN SISHDREEKL QDGKEEEHKV LLEAAPQLSQ HLGSEAGQMK EIHLESDPVL
  1501  NCLTLELHIN GQRLQHQTGF EQTTLETSLQ MGPLEAEELQ KANETENDIK VLGGPKIPPP
  1561  KALQALENSD GLILNAYQKD NELVKSDEEL NQPGSTNIQV QPQTHFTQTI LKSTSCPTLD
  1621  QFPFEKVESH VRFSPLKSGE AKVDEIIFYA REGGISSDSS HQKEQAGGTE KKETAIFGSC
  1681  MPALSTPKTT RNLKQFSDMK TLVNPKCGII KAKKPSISYM LNIRAGAGPK RRKELSCNLT
  1741  TKMKELHQGK KGVDETYAFL TMTPDINKYS KVETEKDTLR EKRLSSTQVK QDTSPHEDSI
  1801  TSRDIKETLL QDEEQEERKQ EALLKVIPQH LQHFMFRSGQ GKDLDFHKLE NQGSRKILFV
  1861  TKQDVPQQLQ PAEPIQREET KKCLQTQNGT ICTVNSKLLP LKSEDSVNGE VLTGAIKRGV
  1921  PTDRKCMGEQ HNSGKGEKAE FNKDLQATVL ELQKSPHGGE AQKANLTDME SGSSNAMNMN
  1981  VQHEREDKNI QKMLTESVPC YSQHLRFSTH QMKDPDPCKS GSEPKSPEGR SWNLSHIVQK
  2041  TKQETHFRET VLEPISGYMM KQSPHMQEGI KCMEGLKTSF PKTGKSKIGS IPRDTPWDEN
  2101  PRRKWDSSIS EKTAWNQKNL QTVLKPLDFS SLMSSEYESR SYTLEFIGKK SMSPKCVTLK
  2161  AKQLRILQLF NIIRYSTENH RKKKQHRFKY KMKGKQWYTS IGEALLSATE YAKSTTSKSM
  2221  IDKLLYNTAA RCILSNRTRR QNLDGHITEE KEEVQENVAA IFLGLLDFFM PVLSDSKNQR
  2281  NTAQLSEKEI IFNAKCLTMK EKKSSISQIH KINRESTRKH RKKCKSYLKT VSNRKCQENH
  2341  GHITEEEEEV QENSPATFLG PLDFFMPVLS DSKNQINTIQ LSERKIILNP KCLTMKEKKP
  2401  PISQIHKISG QFTTKHRKKL ESNLKTKLKA MWQGENVADT FPNTTSFTPD SSDIKRQSGF
  2461  QTEIDMRISG LSHTQPTQIE SLAEGIARYS DPIDKRRTSN LVKGAKLHDR ESGEEKQEHL
  2521  TEMDPFYAEN FMANTYLRKD RHLGKSEDVL LGETFFSKSQ IYKGNSEKNV KIEKNKNGKE
  2581  SLKVGLARME KSDNCAELSE ATDDAISNKY DKQNIGHSVL KENAFCNLAA IVPDSVGRHS
  2641  PASEEMKRQN GRLKMADRSS PQGRPLQAKQ SAVSQSPDTA GYAVVSNNKE QKQNFKAQKT
  2701  EAEVDLIDQE AKINVAEEFN PESVFFSKIH PLQIENKKEF KTADWKTRAD PKTFALPKKQ
  2761  QELCVSGTIW SYPNPYTSIS PKIIRHKDKA KTADVESTMH TKQIKLKAKR ITVSQLLEYG
  2821  TASNKKELRG NIQQQKSFQL SKNAVHRVLK AVYDSGYCVS SIKKLTEVKM EKDKPKDRTC
  2881  ILPQPKLEKP LKEMQRSLSG CTDMSSILRK QEQDIREKEQ KHQSISEDIS QYYIGPLRIS
  2941  SQQINYSSFD APRIRTDEEL EFLIAQRAKE KDVGIAKHSV SIPWEREGSK RLDIPLNSKG
  3001  QNIFFTELDT SQQKTCQEQE LLKQEDISMT NLGSMACPIM EPLHLENTGK VTEEEDVYIN
  3061  RKISSHVLGK EGLKETDIFV GSKGQKFLCT NSEVQHKVPA EQKEQVNPDH VPESILDSES
  3121  FLSKDPLHLK QAVNTARKEN VTISESFNEN LWGKEQSKLD ITLKSNRQKM DFSKKLRMKH
  3181  LSNYYQNKEN ILESVLPCIL HQLYIENPKK EGSAEEIMSS KVLSPMVEKA SHEVGIPVDQ
  3241  PPCSEGIHLN IKGRKEHPQE STHEAFPASV SHSLMDVLQI KSPKVKKALK AINSLGYLTS
  3301  NTKGIGLLFP RQAEKEEKYT YKALPKPASH SKTDLFQFNA SMQQEKLDAM DIPHYDYLTS
  3361  QTREAVKQMD VIVGYTQNSK KRQDLLKTGQ KWQYLPISYE NFWEHISCPQ KYPCLLQHLM
  3421  PQEKEALSEG GNLSSRTPGL DLFSADQLST ITKNRLEWIV PLISPRQMKK QDSMLPLGSY
  3481  HKTIKYASLL FPKGMKSSDG VQVFDLISNN SSPKLRLGKK IETQKANEKV QKEVCLPITL
  3541  HSLSASMPIL QESKGQKDSV EQVIRKGVIC HKRRTSKWKK SVFSHILNTS DCGASSNRLE
  3601  MQWNMTDKMV NVKHRMSEID LVAAKICESI LSLPHFKLNK ETIDGVISSN VKSTKQHISQ
  3661  GKNDRVKAMD MKRIKSPNII LKPRKSSLSH ILSIKEFPLL LDIIKQEGKM QEGKGKSSMK
  3721  LTNLCTSLPS LSHSNSNSRT KAGKDKSGTL KGCLPPLKLQ ASSNARRVSS AESINRDSLS
  3781  NVIESKCFPQ KKKEDRENIV DVKDVMGLKC ITLKGKKSLF RHLLHGKEPQ RSNKKLEKMT
  3841  QEDESNLNVV QNKLCASILS PPHLEWNPRI KEVYMRGITR FCLSSSTQQE LSDTMEKCEQ
  3901  PIDDSLSSIE KAKHMPQKDK DRVEKALEKI MHSKRIALEV KQPSIFQELE LNIKEKGGKI
  3961  QEDKEVEIWS KPFASISFLP YSKVGTIEGE EAMRIKMRSS FSQPNLQESS DTEKTAYEKC
  4021  ISDNISNSVK KALESILQKE QRQKMEKIRA LKKMKSSISQ GIQLDIKEQE KRIEHIKGEP
  4081  SVLLTNACAS IPSPSHLQLD TRREKAEYVT EITRYYLPEL SHQKSSEAGE KADGVASKGD
  4141  ITIKVQKAKD YMQQKEDDEV KISAKKDIMH PEDKGLKAKK ALSQDLPLNT KEPGKMDQEA
  4201  QEQGKEDREG EEQGKEDRRG AGQEKVDRED KEQGKMDHEV EEQQKADGVG IEQGKMDGDK
  4261  NEQERVLFLY LPSNSSLTHY ILDTRIEGEE DQQGIIRPGI LQPRHQKSSE TGKKANGVPS
  4321  EGDSASEVQK AKDYMQQKEE DEVKISAEKD LMHPEDKDLK GKKALSQNLP LNPKEPGKRD
  4381  GEGQEQGKED GEGEEQGNRD GETEEQQQAD GVGTEQEKRD GHKSKQETVL FLHLPSESSL
  4441  TCYELNTRKE GEEDLQGIIK SATLQLRQQK SFDAGKIAHT KSFGVDSSND VKTVQEYKPQ
  4501  KEVDRGKTVS VDYIMQPEGT IFEAEQLSLP HTLNIPGSSG SKTREVLTNI KEKLRHVQER
  4561  KSELDVFLTI PSLSHCKLDK RTAGKKEEQG VTRSFLPPSW HMESSDTGKL KYTLSYLNDI
  4621  TGDSNRTKYM AQIQKDKANI SEKSVMHPEY IAVKAEKSPL SHILKTKELQ VNISQQGEKA
  4681  QEGEVEIVVL LSKTCPFVTS SAFLELDSIK EEEGEPRITR SFMPHLEIQE SLPSRQTAPT
  4741  KPTESLVKKE KQLLPQKEDR VQTVSMHGLM HPNGAVFKAK TSAPPQVFSI TEHSPLSKRK
  4801  EPQWGMKERA GQKQDRTGRP HVILTKTHPF MPSLSHHRFS PSQPKLPISS GAGKSRLANS
  4861  NEGISSHKVI LKANQQMPYK EAKDRVKIEG REGRILPKRI HLRAEALPLA LLCNGKNYSL
  4921  HIEEQGEGVQ ESKKEPGVVP RKSASFPPPP FYLNCDTRRN EKEGTLGKTQ FSFPPLKIQD
  4981  SSDSGKKAYT ESLHGYTLSN SKGPVQPTAQ GEEKGGLRID MEDKMLPKCT DLKAKQLLLS
  5041  DILNTKKLQW KSKEQKRKIQ EDKNKQVKGL PSINTSLLTP PYLKFDTTEG QENVIRIAKV
  5101  SLPQSRSKES SDAGRIACPE ATHGELSSDV KQLKAHLLQK EEKDREKVAD MTSVLDPNKM
  5161  YLKAKKSPVL HTHSFSDLQW KTREQEEEKV QKVKSGPGVM LSKSPSRSSP LHLNVNTGFQ
  5221  EESIPILTRP SFPLVKLQVS PDTEGGTCIR PIAGDILIYL QKGKHVSQNK EEDDVQIVSI
  5281  LIFPKHQEEK VQECEGEPGV VLTKSTSLPS LSQLELDKET HLGNEMLRLK RPILRRISHI
  5341  GETVHRESVV GDIPKDVKNE KQHIPQKEER NQKKIIDMRG TDITLKSKKS PRSCMLHRTE
  5401  LHVNIGGQGR KEHEGQDKPP GMIQRKMCIL FSKPLPSNLK LERATHADEE RLGGKTSFVL
  5461  PLMPSALPDT EKTADAEARS GDVRKGKPHR SQKENRHEVK TIDMRFRIHC QEARISPMSH
  5521  ILNAKELVLN INKLEKKVHK DKDEACVVLS RTFLSIPSAP PLYLDSGNKT DKDTPGITGS
  5581  SCPQRTLHVP SNTQKITNRD SVEGVDKNVV KQAEQYVPRP EAEQQLTSNF MISVQQRNQP
  5641  SRVRSEEDLN QLVLNSRDED IYFTGFGTIR SGKRPEWLFT GKKAQPVKYK TETLTAFLSY
  5701  PTMDATKMGG LEEDTEIMDN LNHKISPKAS VSLIRKISKE LYVTLGTPAN SKGFSVSERY
  5761  AHQQETSSKV SPELAGSCKF DKPKEDGQSN DRISKMFSPK VLAPQTKGSL KKISIVTNWN
  5821  APQNIEEQDI VMKKQVIRRC EHGHKTRTNT ILSKFPLQSG KQKTPSETDV DKKTTAHLSL
  5881  QMLPGIHMDM TEIDPAKGGR KQALLISEQE EGVLEFLPKS LFPPWTFQFQ SGDLEEKHQT
  5941  DANTNINLEQ KKLEMDNDST VNQKEGKLKI GTNRALHLQE EKTEMHKART ANLEKERGRM
  6001  DTSSSAHPHL LSLKAEESQM KTQVITHREN SRLIMQKQKK ELEASNAKQS IQLQKLFQRN
  6061  VLDSFYSYVP LSPKRKDQKG RLTIRDLKRE LSTKYLTMKI QNHPIPQMLN ITGRGTPSNR
  6121  KKLEYDVKLK NIASWSKDVS GIFIRSLSIS IMRSPHTDPK TNLEREKRIC LPKFQEKSPN
  6181  TSEMSKRDTL TIVKGEQNFT NTVPQDPQPF AVDKQQMQKL PNVKSEANLR SEMNKKYLKA
  6241  QTKERIVPEH DVSRIIKKPD LRIIEQEEKI LKRILTPTEC PSMLEDPKLP KQRDQSEPVW
  6301  DMTTQKVQQQ KAFPGTVPIP PQVKSSEVKI VADSTNAEHL LPICEATKAI SESQVKNMIQ
  6361  DKVSSDKLDN IQAYKPDDLK SPPFPEGPDT ISTAIYPKTQ HKSLLEQFTP KEKNKLTSHL
  6421  ESKALEIQLN LIPEMARKSL QMFNFYPKGT ISKDNSWRFY SRHKTMNFMS LEGTDTIEPN
  6481  SKHKHQKDSP LASNMKTLIV DVSSDSEETI TKLQSINKLE NGTSAVTSAS EMLLPHTLQN
  6541  HSVKEKGKLL MHFSVKTLEI QMKAFPRIVR ESYAMTSAHE RKKPLSNCIH PGFTGPKRQN
  6601  RILLLSEEKS LHQIDLDLQY KYLRFLLGLP VGSTFPKPNV LPKHSKLNTI AVCKNVNAGG
  6661  QSGSLSIDTE LLEQHISFKK QSPHENSSLI RKFPQPTLVC ASDRDLHSPR KKDTQVLSES
  6721  EFHVTPEKNK QYHVWFQERN TCESVDLRTQ RNATGSAVSC ETQISEDFVD IQTDIESPAD
  6781  LDECSCLEVS ESEECVFLEA NSYLSQESEN ILFELQTGIP LENVYKITTD LKSFYSEDSG
  6841  SHCTRECRKE TLIITPPSCK SHKSRKYRSS SKMKSPDWLC HSSSNTAEIQ SRSSSVSFSE
  6901  EKISWTTKSR TSYSSAPLTE SNIKSHLAKN QGKSHRHPES QERKKARSDL FRKNSSHWDH
  6961  DYSCTHSKGK RDRKKRVYDY ESERLDCFQS KHKSASKPHH DDINFYSERK QNRPFFFACV
  7021  PADSLEVIPK TIRWTIPPET LRKRNFRIPL VAKISSSWNI WSSSKKLLGS LSGSLTTVFH
  7081  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC168 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

testis: 8.4 nTPM
epididymis: 0.1 nTPM
heart muscle: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

early spermatids: 1,551 nCPM
late spermatids: 61 nCPM
late primary spermatocytes: 20 nCPM
breast myoepithelial cells: 6 nCPM
innate lymphoid cells: 5.7 nCPM
epididymal principal cells: 5.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.6 nTPM
white matter: 0.7 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.2 nTPM
amygdala: 0.1 nTPM
choroid plexus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 2.34

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 168, N-terminal
Leucine-rich repeat transmembrane protein
Coiled-coil domain-containing protein 168

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC168 as an antibody target. Whether an autoantibody or antibody against CCDC168 could matter depends on whether native CCDC168 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC168 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC168 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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