Seroatlas · Human Serome Atlas

CCDC167

Coiled-coil domain-containing protein 167

Also known as: C6orf129, CC167_HUMAN, dJ153P14.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0B6
Gene
CCDC167
Ensembl
ENSG00000198937
Chromosome
6
Canonical length
97 aa
Protein class
Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>Q9P0B6|CCDC167
     1  MTKKKRENLG VALEIDGLEE KLSQCRRDLE AVNSRLHSRE LSPEARRSLE KEKNSLMNKA
    61  SNYEKELKFL RQENRKNMLL SVAIFILLTL VYAYWTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC167 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 84 nTPM
  • tonsil: 66 nTPM
  • liver: 60 nTPM
  • choroid plexus: 53 nTPM
  • spinal cord: 51 nTPM
  • lymph node: 46 nTPM

Single-cell type

  • late spermatids: 463 nCPM
  • oocytes: 212 nCPM
  • esophageal apical cells: 185 nCPM
  • plasma cells: 167 nCPM
  • hepatocytes: 159 nCPM
  • late primary spermatocytes: 144 nCPM

Immune cell

  • T-reg: 425 nTPM
  • memory CD4 T-cell: 231 nTPM
  • memory CD8 T-cell: 178 nTPM
  • MAIT T-cell: 170 nTPM
  • total PBMC: 166 nTPM
  • memory B-cell: 146 nTPM

Brain region

  • white matter: 37 nTPM
  • medulla oblongata: 29 nTPM
  • spinal cord: 28 nTPM
  • cerebellum: 28 nTPM
  • thalamus: 26 nTPM
  • basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 167
  • Coiled-coil domain-containing protein 167

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC167 as an antibody target. Whether an autoantibody or antibody against CCDC167 could matter depends on whether native CCDC167 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC167 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC167 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC167. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...