Seroatlas · Human Serome Atlas

CCDC166

Coiled-coil domain-containing protein 166

Also known as: CC166_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CW27
Gene: CCDC166
Ensembl: ENSG00000255181
Chromosome: 8
Canonical length: 439 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC166 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>P0CW27|CCDC166
     1  MAPKKKRGPS AGSQPGGAAA AGAEQPLSER AQYLQREHAL LSEQLDTCEE SVDQVLRENA
    61  FLDREALRLR EENRLYASYV SARAQRCAKA IVRLDEQNRV DLAQIHWQRA ELASLYHGRE
   121  DGVRAQLLEM EARAAQMAQQ VQELQPYKVL QLEQLARIRA LERELLHMRV EHTQLLHRVK
   181  RRFLEDKAAF EREARQRVQS LARRAEREAV RALVAHTQAI KADNGRLRQE LLLLLRRTQL
   241  LHHTRRQLLE QREQLHREHE DTRDLARVHG WLRRGPGGPP LWERPAFSQP TSRPGSLAAP
   301  ISPSRAASQT PSVVPSRAAP RASSVVPSRE ASRVPSLVLS SMDSRVPSLA TSKVGSRMPS
   361  LTASRAGSRA LSLVQSLEGS GISSGSSPRV SSQDTLRSTK SGPKLLSGLS RDRDPALLPP
   421  QSEDSVNAEA AAEASPGRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC166 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

testis: 3.9 nTPM
cerebral cortex: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

brain excitatory neurons: 0.2 nCPM
brain inhibitory neurons: 0.1 nCPM
other brain neurons: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.2 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC166 as an antibody target. Whether an autoantibody or antibody against CCDC166 could matter depends on whether native CCDC166 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC166 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC166 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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