Seroatlas · Human Serome Atlas

CCDC163

Transmembrane protein CCDC163

Also known as: C1orf231, CC163_HUMAN, CCDC163P, LOC126661

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0D9SF12
Gene
CCDC163
Ensembl
ENSG00000280670
Chromosome
1
Canonical length
145 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>A0A0D9SF12|CCDC163
     1  MNTSLSWFEQ LDVLLNATDG NVVRNKQWLY PLGVSTELIG LCICFFCSSG CIFLGSPPQN
    61  STAVTPAVLW EESEIMQKEL KLLQYQLSQH QELLLKQLAE GRQAQVGSWK IPRGAPFLTW
   121  SPASFSSMPR VLSKRTYSFG APKCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC163 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 1.4 nTPM
  • bone marrow: 0.9 nTPM
  • parathyroid gland: 0.7 nTPM
  • salivary gland: 0.7 nTPM
  • spleen: 0.7 nTPM
  • thyroid gland: 0.7 nTPM

Single-cell type

  • astrocytes: 18 nCPM
  • bergmann glia: 9.5 nCPM
  • breast lactating cells: 9 nCPM
  • breast myoepithelial cells: 8.6 nCPM
  • plasma cells: 8.3 nCPM
  • adrenal cortex cells: 7.1 nCPM

Immune cell

  • basophil: 1 nTPM
  • eosinophil: 0.7 nTPM
  • gdT-cell: 0.7 nTPM
  • MAIT T-cell: 0.7 nTPM
  • plasmacytoid DC: 0.7 nTPM
  • naive CD8 T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 1 nTPM
  • hippocampal formation: 0.6 nTPM
  • medulla oblongata: 0.6 nTPM
  • pons: 0.5 nTPM
  • thalamus: 0.5 nTPM
  • amygdala: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC163 as an antibody target. Whether an autoantibody or antibody against CCDC163 could matter depends on whether native CCDC163 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC163 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC163 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC163. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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