Seroatlas · Human Serome Atlas

CCDC160

Coiled-coil domain-containing protein 160

Also known as: CC160_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGH7
Gene: CCDC160
Ensembl: ENSG00000203952
Chromosome: X
Canonical length: 325 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC160 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>A6NGH7|CCDC160
     1  MDARRKHWKE NMFTPFFSAQ DVLEETSEPE SSSEQTTADS SKGMEEIYNL SSRKFQEESK
    61  FKRKKYIFQL NEIEQEQNLR ENKRNISKNE TDTNSASYES SNVDVTTEES FNSTEDNSTC
   121  STDNLPALLR QDIRKKFMER MSPKLCLNLL NEELEELNMK YRKIEEEFEN AEKELLHYKK
   181  EIFTKPLNFQ ETETDASKSD YELQALRNDL SEKATNVKNL SEQLQQAKEV IHKLNLENRN
   241  LKEAVRKLKH QTEVGNVLLK EEMKSYYELE MAKIRGELSV IKNELRTEKT LQARNNRALE
   301  LLRKYYASSM VTSSSILDHF TGDFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC160 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 12 nTPM
kidney: 4.4 nTPM
parathyroid gland: 3.8 nTPM
midbrain: 3.7 nTPM
choroid plexus: 3.6 nTPM
breast: 3 nTPM

Single-cell type

respiratory ciliated cells: 47 nCPM
oocytes: 46 nCPM
epididymal efferent duct ciliated cells: 41 nCPM
fallopian tube ciliated cells: 39 nCPM
lacrimal acinar cells: 37 nCPM
endometrial ciliated cells: 32 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 7.2 nTPM
cerebellum: 5.2 nTPM
pons: 5.2 nTPM
cerebral cortex: 4.8 nTPM
medulla oblongata: 4.8 nTPM
midbrain: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.02
gnomAD missense Z: -0.14
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC160 as an antibody target. Whether an autoantibody or antibody against CCDC160 could matter depends on whether native CCDC160 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC160 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC160 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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