Seroatlas · Human Serome Atlas

CCDC157

Coiled-coil domain-containing protein 157

Also known as: CC157_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q569K6
Gene: CCDC157
Ensembl: ENSG00000187860
Chromosome: 22
Canonical length: 752 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC157 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

752 residues, UniProt reviewed canonical sequence.

>Q569K6|CCDC157
     1  MAHLLGSQAC MESLRTDLTD LQGAIVDVFS RAGPVRFPSW KFPDRMACDL DMVALLEHYD
    61  HVPGDPEFTQ LSHAVLLELV IDRLLLLLQS CMSYLENLGS EQMMPPAQAA GPCMSVGLTV
   121  RRFWDSLLRL GTLHQQPLPQ KGANQRETPT SKPTTKGEPA RSPEYLTTKL IKPSSPVLGL
   181  PQTCQEPESI PVRASLQFPA TTFKNTRSVH SQTIETALVP CDACASVQGS LQKVGKVVIS
   241  LCQSQNLPSS LGQFQQLVQD SMGLRPLPAA TVGRWAAEQR KDLTRLSKHV EALRAQLEEA
   301  EGQKDGLRKQ AGKLEQALKQ EQGARRRQAE EDEQCLSEWE HDKQQLLTET SDLKTKMATL
   361  ERELKQQRES TQAVEAKAQQ LQEEGERRAA AERQVQQLEE QVQQLEAQVQ LLVGRLEGAG
   421  QQVCWASTEL DKEKARVDSM VRHQESLQAK QRALLKQLDS LDQEREELRG SLDEAEAQRA
   481  RVEEQLQSER EQGQCQLRAQ QELLQSLQRE KQGLEQATTD LRLTILELER ELEELKERER
   541  LLVAFPDLHR PTETQIHGGR SSSVESQITC PTDSGNVTDH MERQVQSNDI RIRVLQEENG
   601  RLQSMLSKIR EVAQQGGLKL IPQDRLWSPS SKGTQGATPP VQAKSTSPGP LGRQHLPSSR
   661  TGRTLLGQPC TSPPRQPCTS PPRQPCTSPP RQPCTSPSRQ PCSQPSKSLL EGVTHLDTCT
   721  QNPIKVLVRL RKRLSPGRGQ ASSAHQPQER PM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC157 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
fallopian tube: 7.3 nTPM
hypothalamus: 6.6 nTPM
choroid plexus: 6 nTPM
pituitary gland: 5.4 nTPM
hippocampal formation: 5.1 nTPM

Single-cell type

late spermatids: 237 nCPM
late primary spermatocytes: 135 nCPM
early spermatids: 116 nCPM
respiratory ciliated cells: 85 nCPM
fallopian tube ciliated cells: 71 nCPM
epididymal efferent duct ciliated cells: 68 nCPM

Immune cell

neutrophil: 2.8 nTPM
basophil: 1.1 nTPM
NK-cell: 1.1 nTPM
plasmacytoid DC: 1 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.9 nTPM

Brain region

choroid plexus: 15 nTPM
midbrain: 13 nTPM
hypothalamus: 11 nTPM
medulla oblongata: 9.6 nTPM
basal ganglia: 8.5 nTPM
cerebral cortex: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 157

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC157 as an antibody target. Whether an autoantibody or antibody against CCDC157 could matter depends on whether native CCDC157 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC157 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC157 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...