Seroatlas · Human Serome Atlas

CCDC154

Coiled-coil domain-containing protein 154

Also known as: C16orf29, CC154_HUMAN, LOC645811

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NI56
Gene
CCDC154
Ensembl
ENSG00000197599
Chromosome
16
Canonical length
667 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in bone mineralization involved in bone maturation. Predicted to act upstream of or within bone resorption; odontogenesis; and sensory perception of sound. Predicted to be located in early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

667 residues, UniProt reviewed canonical sequence.

>A6NI56|CCDC154
     1  MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE SSHPTSTASV
    61  PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL LRELLQVRAR VQLQGSELRQ
   121  LQQEARPAAQ APEKEAPEFS GLQNQMQALD KRLVEVREAL TRLRRRQVQQ EAERRGAEQE
   181  AGLRLAKLTD LLQQEEQGRE VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL
   241  KREAKLCGFL QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ
   301  HEESHLLEQC QGLDAAVAQL TKFVQQNQAS LNRVLLAEEK AWDAKGRLEE SRAGELAAYV
   361  QENLEAAQLA GELARQEMHG ELVLLREKSR ALEASVAQLA GQLKELSGHL PALSSRLDLQ
   421  EQMLGLRLSE AKTEWEGAER KSLEDLARWR KEVTEHLRGV REKVDGLPQQ IESVSDKCLL
   481  HKSDSDLRIS AEGKAREFKV GALRQELATL LSSVQLLKED NPGRKIAEMQ GKLATFQNQI
   541  MKLENCVQAN KTIQNLRFNT EARLRTQEMA TLWESVLRLW SEEGPRTPLG SWKALPSLVR
   601  PRVFIKDMAP GKVVPMNCWG VYQAVRWLRW KASLIKLRAL RRPGGVLEKP HSQEQVQQLT
   661  PSLFIQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC154 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • cerebellum: 3.9 nTPM
  • pituitary gland: 3.7 nTPM
  • thyroid gland: 2.7 nTPM
  • kidney: 2.6 nTPM
  • spleen: 2.1 nTPM

Single-cell type

  • early spermatids: 50 nCPM
  • late primary spermatocytes: 49 nCPM
  • late spermatids: 14 nCPM
  • retinal horizontal cells: 14 nCPM
  • retinal amacrine cells: 13 nCPM
  • melanocytes: 12 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 5.7 nTPM
  • medulla oblongata: 5.2 nTPM
  • cerebral cortex: 4.9 nTPM
  • basal ganglia: 4.6 nTPM
  • cerebellum: 4.5 nTPM
  • pons: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 154
  • Coiled-coil domain-containing protein 154

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC154 as an antibody target. Whether an autoantibody or antibody against CCDC154 could matter depends on whether native CCDC154 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC154 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC154 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC154. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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