Seroatlas · Human Serome Atlas

CCDC152

Coiled-coil domain-containing protein 152

Also known as: CC152_HUMAN, LOC100129792

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4G0S7
Gene: CCDC152
Ensembl: ENSG00000198865
Chromosome: 5
Canonical length: 254 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC152 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q4G0S7|CCDC152
     1  MDQSSEGCMK KISSVNLDKL INDFSQIEKK MVETNGKNNI LDIQLEKSNC LLKVMQAKEV
    61  SIKEECATLH NIIKGLQQTI EYQQNLKGEN EQLKISADLI KEKLKSHEQE YKNNIAKLVS
   121  EMKIKEEGYK KEISKLYQDM QRKVELNEEK HKELIEKKEM EISELNAKLR SQEKEKQNEI
   181  IKLQLEFDAK LARVQTKSKS YQDSTVLPQS IYRRKLQHFQ EEKNKEIAIL RNTIRDLEQR
   241  LSVGKDSHLK RRRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC152 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

liver: 126 nTPM
spinal cord: 17 nTPM
spleen: 12 nTPM
small intestine: 11 nTPM
midbrain: 9 nTPM
ovary: 7.4 nTPM

Single-cell type

early primary spermatocytes: 164 nCPM
pituicytes/fscs: 48 nCPM
differentiating spermatogonia: 38 nCPM
retinal horizontal cells: 38 nCPM
müller glia: 36 nCPM
somatotrophs: 33 nCPM

Immune cell

plasmacytoid DC: 8.3 nTPM
NK-cell: 5.1 nTPM
naive CD8 T-cell: 4.8 nTPM
memory CD8 T-cell: 3.9 nTPM
MAIT T-cell: 3.7 nTPM
gdT-cell: 3.1 nTPM

Brain region

pons: 17 nTPM
white matter: 16 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 13 nTPM
hypothalamus: 12 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 152

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC152 as an antibody target. Whether an autoantibody or antibody against CCDC152 could matter depends on whether native CCDC152 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC152 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC152 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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