Seroatlas · Human Serome Atlas

CCDC150

Coiled-coil domain-containing protein 150

Also known as: CC150_HUMAN, FLJ39660

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCX0
Gene: CCDC150
Ensembl: ENSG00000144395
Chromosome: 2
Canonical length: 1101 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for CCDC150 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1101 residues, UniProt reviewed canonical sequence.

>Q8NCX0|CCDC150
     1  MDCKVHMETT VSRPVLSPTH INATASETFT VLQQRMRIVE EQTSSLRDDL IMLDFGEKRG
    61  YLEAPDCLED LDSQKVISPI QNEAICAGKT DILWKNCEFL VNRMCRLESL MQSLKMNIFR
   121  LQTEKDLNPQ KTAFLKDRLN AIQEEHSKDL KLLHLEVMNL RQQLRAVKEE EDKAQDEVQR
   181  LTATLKIASQ TKKNAAIIEE ELKTTKRKMN LKIQELRRQL AQEKYLRESL EKSASAMLLK
   241  IQEMGSTVEV ERKQVHILQQ NCIALRDSIQ SAQELLAQEQ KKKEELEIAT SQLKSDLTSR
   301  DDLISKLVEE NKNLQISFNK EHEENAYLRS EIMSLHEASE KAQVLNDQLT KKCSELSCML
   361  QTVTMEKARI IADHQAILQV EQKMMTQTFQ EQNLLLDAAH ASITNELQTV QNEKTQLQAH
   421  LDHLILEHNQ CIQKAQDAEK RTAVQKELLE STIARLRGEL EASMQEKKSL LEEKERFQRE
   481  VNKTEKEIVQ ERCNLEKELA KNKVDINTLT HNLQTLEEEN KHLADQMASL ELQQVTSDYH
   541  GLAQQKVEKI TESKNKLAYE NGKLQIKVKQ LEEQVQSFTD TSLQNDHLRK MNKYLQTKYA
   601  QANSELSAKR VHLQQADAHL KEVKSILERS KEELSRTVKC RNAALKESQK LKEDLEAVED
   661  RENKKVGNFQ RQLAEAKEDN CKVTIMLENV LASHSKMQGA LEKVQIELGR RDSEIAGLKK
   721  ERDLNQQRVQ KLEAEVDQWQ ARMLVMEDQH NSEIESLQKA LGVAREDNRK LAMSLEQALQ
   781  TNNHLQTKLD HIQEQLESKE LERQNLETFK DRMTEESKVE AELHAERIEA LRKQFQTERE
   841  TTKKVAQREV AELKKALDEA NFRSVEVSRT NRELRQKLAE LEKILESNKE KIKNQKTQIK
   901  LHLSAKANNA QNIERMKQIE KELKQMELIK DQYQKKNYEQ SLSIQRFVCE MTNLQKEMQM
   961  LAKSQYDASV RNKQQELHLE AERKIRQELE NRCQELEETV RHLKKCKEAT ENTLKEASVE
  1021  SEQITANLEE AHRWFKHRFD GLQLELTKNR LQRPSGEDRW QEKDQDVKHD VMSNQSVLHR
  1081  WERKQNLRPM PKKYHSEVQR K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC150 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

testis: 4.6 nTPM
kidney: 2.4 nTPM
liver: 1.1 nTPM
thymus: 1 nTPM
bone marrow: 0.5 nTPM
appendix: 0.2 nTPM

Single-cell type

late primary spermatocytes: 83 nCPM
early primary spermatocytes: 43 nCPM
undifferentiated spermatogonia: 38 nCPM
early spermatids: 37 nCPM
oocytes: 32 nCPM
monocyte progenitors: 30 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.3 nTPM
pons: 0.3 nTPM
spinal cord: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 150

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC150 as an antibody target. Whether an autoantibody or antibody against CCDC150 could matter depends on whether native CCDC150 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC150 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC150 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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