Seroatlas · Human Serome Atlas

CCDC149

Coiled-coil domain-containing protein 149

Also known as: CC149_HUMAN, DKFZp761B107

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUS6
Gene: CCDC149
Ensembl: ENSG00000181982
Chromosome: 4
Canonical length: 474 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

No narrative summary is available for CCDC149 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q6ZUS6|CCDC149
     1  MANQLRERHQ SLKKKYRELI DGDPSLPPEK RKQANLAQLL RDSQDRNKHL GEEIKELQQR
    61  LGEVQGDNKL LRMTIAKQRL GDEAIGVRHF AAHEREDLVQ QLERAKEQIE SLEHDLQASV
   121  DELQDVKEER SSYQDKVERL NQELNHILSG HENRIIDVDA LCMENRYLQE RLKQLHEEVN
   181  LLKSNIAKYK NALERRKNSK GQGKSSSSAL TGVLSAKQVQ DLLSEDHGCS LPATPQSISD
   241  LKSLATALLE TIHEKNMVIQ HQRQTNKILG NRVAELEKKL RTLEVSGLWS LPGGKDTILF
   301  SDPTLPSGQR SRSPLLKFVE QPTENKADPK DGEAQKQEED ESCAAAEALT APEDAGRPAV
   361  NSPANQSRGN QCKLFHPSLP QLPSEEEVNS LGREIIKLTK EQAAAELEEV RRESPIEGQR
   421  SETGPAPPGL AIQGELPKSH LDSFEASRPA AKASTPEDGK GIPEGGGMRS TVKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC149 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

pancreas: 18 nTPM
salivary gland: 17 nTPM
cerebral cortex: 12 nTPM
stomach: 12 nTPM
breast: 11 nTPM
blood vessel: 11 nTPM

Single-cell type

lymphatic endothelial cells: 76 nCPM
pancreatic acinar cells: 65 nCPM
lacrimal acinar cells: 64 nCPM
salivary acinar cells: 64 nCPM
choroid plexus epithelial cells: 62 nCPM
prostatic glandular cells: 56 nCPM

Immune cell

classical monocyte: 1.5 nTPM
intermediate monocyte: 0.5 nTPM
non-classical monocyte: 0.5 nTPM
total PBMC: 0.5 nTPM
neutrophil: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM

Brain region

cerebral cortex: 26 nTPM
hypothalamus: 24 nTPM
basal ganglia: 24 nTPM
white matter: 22 nTPM
hippocampal formation: 22 nTPM
amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 149
Coiled-coil domain-containing protein 149-A

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC149 as an antibody target. Whether an autoantibody or antibody against CCDC149 could matter depends on whether native CCDC149 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC149 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC149 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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