Seroatlas · Human Serome Atlas

CCDC144NL

Putative coiled-coil domain-containing protein 144 N-terminal-like

Also known as: C144L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NUI1
Gene: CCDC144NL
Canonical length: 221 aa

OverviewNCBI Gene

No narrative summary is available for CCDC144NL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q6NUI1|CCDC144NL
     1  MASWGGEKRG GAGGSPKPAV YATRKTPSVG SQEDQWYLDY PGDQWSLGFS YSWWKNSVGS
    61  ESKHGEGALD QLQHDVRLED LGELHRAARS GDVPGVEHVL APGDTGVDKR DRKKSIQQLV
   121  PEYKEKQTPE SLPQNNNPAA PSQAEGGEGG VACGTVEQMT WLCSLPHAVG GGDGDHSSTG
   181  AVGGHPRGPG EYCHLHEQRV HHHIFARGKR KGKNHVSNVV R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC144NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -3.19

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 144A/B/C

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC144NL as an antibody target. Whether an autoantibody or antibody against CCDC144NL could matter depends on whether native CCDC144NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC144NL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC144NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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