Seroatlas · Human Serome Atlas

CCDC144CP

Putative coiled-coil domain-containing protein 144C

Also known as: C144C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYA2
Gene: CCDC144CP
Canonical length: 1237 aa

OverviewNCBI Gene

No narrative summary is available for CCDC144CP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1237 residues, UniProt reviewed canonical sequence.

>Q8IYA2|CCDC144CP
     1  MVSWGGEKRG GAEGSPKPAV YATRKTGSVR SQEDQWYLGY PGDQWSSGFS YSWWKNSVGS
    61  ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHVL VPGDTGVDKR DRKKSIQQLV
   121  PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE TCQRSKNLKV DDKCPSVSPS MPENQSATKE
   181  LGQMNLTERE KMDTGVKTSQ EPEMAKDCDR EDIPIYPVLP HVQKSEEMRI EQGKLEWKNQ
   241  LKLVINELKQ RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS
   301  EISVSVVFET FPEQKEPSLK NIIHSYYHPY SGSQEHVCQS SSKLHLHENK LDCDNDNKPG
   361  IGHIFSTDKN FHNDASTKKA RNPEVVTVEM KEDQEFDLQM TKNMNQNSDS GSTNNYKSLK
   421  PKLENLSSLP PDSDRTSEVY LHEELQQDMQ KFKNEVNTLE EEFLALKKEN VQLHKEVEEE
   481  MEKHRSNSTE LSGTLTDGTT VGNDDDGLNQ QIPRKENGEH DRLALKQENE EKRNADMLYN
   541  KDSEQLRIKE EECGKVVETK QQLKWNLRRL VKELRTVVQE RNDAQKQLSE EQDARILQDQ
   601  ILTSKQKELE MAQKKRNPEI SHRHQKEKDL FHENCMLQEE IALLRLEIDT IKNQNKQKEK
   661  KYFEDIEVVK EKNDNLQKII KRNEETLTET ILQYSGQLNN LTAENKMLNS ELENGKENQE
   721  RLEIEMESYR CRLAAAVHDC DQSQTARDLK LDFQRTRQEW VRLHDKMKVD MSGLQAKNEI
   781  LSEKLSNAES KINSLQIQLH NTRDALGRES LILERVQRDL SQTQCQKKET EQMYQSKLKK
   841  YIAKQESVEE RLSQLQSENM LLRQQLDDVH KKANSQEKTI STIQDQFHSA AKNLQAESEK
   901  QILSLQEKNK ELMDEYNHLK ERMDQCEKEK AGRKIDLTEA QETVPSRCLH LDAENEVLQL
   961  QQTLFSMKAI QKQCETLQKN KKQLKQEVVN LKSYMERNML ERGEAEWHKL LIEERARKEI
  1021  EEKLNEAILT LQKQAAVSHE QLAQLREDNT TSIKTQMELT VIDLESEISR IKTSQADFNK
  1081  TKLERYKELY LEEVKVRESL SNELSRTNEM IAEVSTQLTV EKEQTRSRSL FTAYATRPVL
  1141  ESPCVGNLND SEGLNRKHIP RKKRSALKDM ESYLLKMQQK LQNDLTAEVA GSSQTGLHRI
  1201  PQCSSFSSSS LHLLLCSICQ PFFLILQLLL NMNLDPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC144CP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC144CP as an antibody target. Whether an autoantibody or antibody against CCDC144CP could matter depends on whether native CCDC144CP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC144CP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC144CP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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