Seroatlas · Human Serome Atlas

CCDC144BP

Putative coiled-coil domain-containing protein 144B

Also known as: C144B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3MJ40
Gene
CCDC144BP
Canonical length
725 aa

OverviewNCBI Gene

No narrative summary is available for CCDC144BP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q3MJ40|CCDC144BP
     1  MASWGGEKRG GAEGSPKLAV YATRKTRSVR SQEDQWYLGY PGDQWSSGFS YSWWKNSVGS
    61  ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHVL APGDTGVDKR DRKKSIQQLV
   121  PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE TCQRSKNLKV GDKSPSVSPS MPENQSATKE
   181  LGQMNLTERE KMDTGVVLLS GNDTLHDLCQ SQLPENKESK EAEQDLELTS EEEQERLKGC
   241  ENKQPQKTSQ EPEMAKDCDR EDIPIYPVLP HVQKSEEMWI EQGKLEWKNQ LKLVINELKQ
   301  RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS EISVSVVFET
   361  FPEQKEPSLK NIIHPYYHPY SGSQEHVCQS SSKLHLHENK LDCDNDNKLG IGHIFSTDNN
   421  FHNDASTKKA RNPEVVTVEM KEDQEFDLQM TKNMNQNSDS GSTNNYKSLK PKLENLSSLP
   481  PDSDRTSEVY LHEELQQDMQ KFKNEVNTLE EEFLALKKEN VQLHKEVEEE MEKHRSNSTE
   541  LSGTLTDGTT VGNDDDGLNQ QIPRKENEEH DRPADKTANE KNKVKNQIYP EADFADSMEP
   601  SEIASEDCEL SHSVYENFML LIEQLRMEYK DSASLPRIQD TFCLCEHLLK LKNNHCDQLT
   661  VKLKQMENMV SVLQNELSET KKTKLQLELQ KIEWEKELYD LRLALKQENG RKEMPICCII
   721  KIVNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC144BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC144BP as an antibody target. Whether an autoantibody or antibody against CCDC144BP could matter depends on whether native CCDC144BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC144BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC144BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC144BP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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