Seroatlas · Human Serome Atlas

CCDC144A

Coiled-coil domain-containing protein 144A

Also known as: C144A_HUMAN, FLJ43983, KIAA0565

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RUR9
Gene: CCDC144A
Ensembl: ENSG00000170160
Chromosome: 17
Canonical length: 1427 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to enable calcium oxalate binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1427 residues, UniProt reviewed canonical sequence.

>A2RUR9|CCDC144A
     1  MASWGGEKRG GAEGSPKPAV YATRKTPSVG SQGDQWYLGY PGDQWSSGFP YSWWKNSVGS
    61  ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHIL APGDTGVDKR DRKKSIQQLV
   121  PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE TCQRSKNLKV DDKCPSVSPS MPENQSATKE
   181  LGQMNLTERE KMDTGVVLLS GNDTLHDLCQ SQLPENKESK EAEQDSELTS EEEQERLKGC
   241  ENKQPQKTSQ EPEMAKDCDR EDIPIYPVLP HVQKSEEMWI EQGKLEWKNQ LKLVINELKQ
   301  RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS EISVSVVFET
   361  FPEQKEPSLK NIIHPYYHPY SGSQEHVCQS SSKFHLHENK LDCDNDNKPG IGHIFSTDKN
   421  FHNDASTKKA RNPEVVMVEM KEDQEFDLQM TKNMNQNSDS GSTNNYKSLK PKLENLSSLP
   481  PDSDRTSEVY LHEELQQDMQ KFKNEVNTLE EEFLALKKED VQLHKDVEEE MEKHRSNSTE
   541  LSGTLTDGTT VGNDDDGLNQ QIPRKENGEH DRPADKTSNE KNEVKNQIYP EADFADSMEP
   601  SEIASEDCEL SHSVYENFML LIEQLRMEYK DSASLPRIQD TFCLCEHLLK LKNNHCDQLT
   661  VKLKQMENMV SVLQNELSET KKTKLQLELQ KIEWEKELYD LRLALKQENE EKRNADMLYN
   721  KDSEQLRIKE EECGKVVETK QQLKWNLRRL VKELRTVRNN LDLVVQERND AQKQLSEEQD
   781  ARILQDQILT SKQKELEMAR KKMNSEISHR HQKEKDLFHE DCMLQEEIAL LRLEIDTIKN
   841  QNKQKEKKYF EDIEAVKEKN DNLQKIIKLN EETLTETILQ YSGQLNNLTA ENKILNSELE
   901  NGKQNQERLE IEMESYRCRL AAAVRDCDQS QTARDLKLDF QRTRQEWVRL HDKMKVDMSG
   961  LQAKNEILSE KLSNAESKIN SLQIQLHNTR DALGRESLIL ERVQRDLSQT QCQKKETEQM
  1021  YQIEQSKLKK YIAKQESVEE RLSQLQSENM LLRQQLDDAH KKANSQEKTS STIQDQFHSA
  1081  AKNLQAESEK QILSLQEKNK ELMDEYNHLK ERMDQCEKEK AGRKIDLTEA QETVPSRCLH
  1141  LDAENEVLQL QQTLFSMKAI QKQCETLQKN KKQLKQEVVN LKSYMERNML ERGKAEWHKL
  1201  LIEERARKEI EEKLNEAILT LQKQAAVSHE QLVQLREDNT TSIKTQMELT IKDLESEISR
  1261  IKTSQADFNK TELERYKELY LEEVKVRESL SNELSRTNEM IAEVSTQLTV EKEQTRSRSL
  1321  FTAYATRPVL ESPCVGNLND SEGLNRKHIP RKKRSALKDM ESYLLKMQQK LQNDLTAEVA
  1381  GSSQTGLHRI PQCSSFSSSS LHLLLCSICQ PFFLILQLLL NMNLDPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC144A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

retina: 12 nTPM
testis: 9.5 nTPM
bone marrow: 7.6 nTPM
cerebellum: 5.7 nTPM
thymus: 4.1 nTPM
placenta: 3.8 nTPM

Single-cell type

brain excitatory neurons: 76 nCPM
oligodendrocyte progenitor cells: 63 nCPM
oligodendrocytes: 60 nCPM
astrocytes: 57 nCPM
brain inhibitory neurons: 49 nCPM
bergmann glia: 44 nCPM

Immune cell

basophil: 1.2 nTPM
naive CD4 T-cell: 0.9 nTPM
gdT-cell: 0.6 nTPM
memory CD4 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM
neutrophil: 0.5 nTPM

Brain region

cerebellum: 94 nTPM
white matter: 76 nTPM
cerebral cortex: 73 nTPM
hippocampal formation: 66 nTPM
pons: 60 nTPM
basal ganglia: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 2.02
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC144A as an antibody target. Whether an autoantibody or antibody against CCDC144A could matter depends on whether native CCDC144A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC144A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC144A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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