Seroatlas · Human Serome Atlas

CCDC142

Coiled-coil domain-containing protein 142

Also known as: CC142_HUMAN, FLJ14397

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RM4
Gene: CCDC142
Ensembl: ENSG00000135637
Chromosome: 2
Canonical length: 750 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC142 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

750 residues, UniProt reviewed canonical sequence.

>Q17RM4|CCDC142
     1  MAQASRSGSL PPLVIVPPLR AQPGGTGEEQ WERSRTGGLR WEVHCWPSGT SGGTPWWPTP
    61  ADVSEDYEAD AAAWRRGPAG GGPIPPALQR LRAVLLRLHR EREQLLQARD CAYHLQSAVR
   121  LMKTLSPGSP SGGPSPLPQW CRDLQLHPSQ GAVLRIGPGE TLEPLLLARP IGLAAQCLEA
   181  VIEMQLRALG REPASPGLSS QLAELLFALP AYHTLQRKAL SHVPGAARPF PTSRVLRLLT
   241  GERGCQVASR LDEALQGSAL RDQLRRRCQE EGDLLPGLLG LVGGVAGSAS CGLGLGGAGA
   301  LWSQYWTLLW AACAQSLDLN LGPWRDPRAT AQQLSQALGQ ASLPQECEKE LASLCHRLLH
   361  QSLIWSWDQG FCQALGSALG GQSSLPTSSG TAELLQQLFP PLLDALREPR LRRIFCQPAD
   421  PAPVALGLCT LQTTLLWFLG RAQQYLAAWD PASFLLLIQK DLPPLLHEAE ALYSLASEES
   481  LALEVEQQLG LEIQKLTAQI QLLPEESLSV FSQECHKQAM QGFKLYMPRG RYWRLRLCPE
   541  PPSAPSEYAG LVVRTVLEPV LQGLQGLPPQ AQAPALGQAL TAIVGAWLDH ILTHGIRFSL
   601  QGALQLKQDF GVVRELLEEE QWSLSPDLRQ TLLMLSIFQQ LDGALLCLLQ QPLPKSQVHR
   661  RPPCCCACQE VQTTKLPSSC LNSLESLEPP LQPGTSPAQT GQLQSTLGGR GPSPEGYLVG
   721  NQQAWLALRQ HQRPRWHLPF FSCLGTSPES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC142 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

liver: 5.1 nTPM
cerebellum: 4.5 nTPM
duodenum: 4.1 nTPM
spleen: 3.8 nTPM
testis: 3.7 nTPM
small intestine: 3.6 nTPM

Single-cell type

cardiomyocytes: 24 nCPM
tuft cells: 23 nCPM
parietal cells: 23 nCPM
adipocytes: 16 nCPM
proximal tubule cells: 15 nCPM
podocytes: 15 nCPM

Immune cell

basophil: 6.2 nTPM
eosinophil: 5.9 nTPM
naive B-cell: 5.2 nTPM
gdT-cell: 5.1 nTPM
naive CD4 T-cell: 4.6 nTPM
NK-cell: 4.6 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 10 nTPM
choroid plexus: 9.5 nTPM
cerebral cortex: 9.3 nTPM
medulla oblongata: 9.2 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 142
Coiled-coil protein 142, C-terminal
CC142, N-terminal
Coiled-coil protein 142
CC142 N-terminal

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC142 as an antibody target. Whether an autoantibody or antibody against CCDC142 could matter depends on whether native CCDC142 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC142 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC142 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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