Seroatlas · Human Serome Atlas

CCDC141

Coiled-coil domain-containing protein 141

Also known as: CAMDI, CC141_HUMAN, FLJ39502

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZP82
Gene
CCDC141
Ensembl
ENSG00000163492
Chromosome
2
Canonical length
1530 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in brain development. Predicted to act upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Predicted to be located in centrosome and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1530 residues, UniProt reviewed canonical sequence.

>Q6ZP82|CCDC141
     1  MSSQGSPSVA LSTTTVSSVA VQAGDSKIVI AVIKCGKWVQ LQLAESQPNL LEIGSSQDET
    61  KKLLHDHELL LAKLKALEDR VWELLQEADK TAEENKDQSQ VYDAMAETLG EAWAALVSML
   121  ERRTELLRLT SEFFENALEF AIKIDQAEDF LQNTHEFESA ESLKSLLQLH EHHTKELLER
   181  SLALLNKSQQ LTDFIEKFKC EGPNVNPELT QGAHSSCLKV DRLLELLQDR RRQLDKYLKQ
   241  QWQELSQVLQ ICQWDQQENQ VTCWFQKTIR NLQEQSLGSS LSDNEDRIHK QEELIIKAKE
   301  WNSAVEKLKS EALRILLSKD YVEKEHLQLS HQKLSQLQEE FGQLMVERNT WLKKANEFFN
   361  SANKAFDVLG RVEAYLKLLK SEGLSLAVLA VRHEELHRKI KDCTTDALQK GQTLISQVDS
   421  CSSQVSGIHE MMGCIKRRVD HLTEQCSAHK EYALKKQQLT ASVEGYLRKV EMSIQKISPV
   481  LSNAMDVGST RSESEKILNK YLELDIQAKE TSHELEAAAK TMMEKNEFVS DEMVSLSSKA
   541  RWLAEELNLF GQSIDYRSQV LQTYVAFLKS SEEVEMQFQS LKEFYETEIP QKEQDDAKAK
   601  HCSDSAEKQW QLFLKKSFIT QDLGLEFLNL INMAKENEIL DVKNEVYLMK NTMENQKAER
   661  EELSLLRLAW QLKATESKPG KQQWAAFKEQ LKKTSHNLKL LQEALMPVSA LDLGGSLQFI
   721  LDLRQKWNDM KPQFQQLNDE VQYIMKESEE LTGRGAPVKE KSQQLKDLIH FHQKQKERIQ
   781  DYEDILYKVV QFHQVKEELG RLIKSRELEF VEQPKELGDA HDVQIHLRCS QEKQARVDHL
   841  HRLALSLGVD IISSVQRPHC SNVSAKNLQQ QLELLEEDSM KWRAKAEEYG RTLSRSVEYC
   901  AMRDEINELK DSFKDIKKKF NNLKFNYTKK NEKSRNLKAL KYQIQQVDMY AEKMQALKRK
   961  MEKVSNKTSD SFLNYPSDKV NVLLEVMKDL QKHVDDFDKV VTDYKKNLDL TEHFQEVIEE
  1021  CHFWYEDASA TVVRVGKYST ECKTKEAVKI LHQQFNKFIA PSVPQQEERI QEATDLAQHL
  1081  YGLEEGQKYI EKIVTKHKEV LESVTELCES LTELEEKLKQ GDVLKMNPNL EDFHYDYIDL
  1141  LKEPAKNKQT IFNEERNKGQ VQVADLLGIN GTGEERLPQD LKVSTDKEGG VQDLLLPEDM
  1201  LSGEEYECVS PDDISLPPLP GSPESPLAPS DMEVEEPVSS SLSLHISSYG VQAGTSSPGD
  1261  AQESVLPPPV AFADACNDKR ETFSSHFERP YLQFKAEPPL TSRGFVEKST ALHRISAEHP
  1321  ESMMSEVHER ALQQHPQAQG GLLETREKMH ADNNFTKTQD RLHASSDAFS GLRFQSGTSR
  1381  GYQRQMVPRE EIKSTSAKSS VVSLADQAPN FSRLLSNVTV MEGSPVTLEV EVTGFPEPTL
  1441  TWYKKGQKLS ADGHLQVLHK ETRHSVFIPK VCKADAGLYV ARAQNSSGAL SSNVILHVTG
  1501  NCRLPITRVN WITLCVVYVS VSLMYWLLTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 70 nTPM
  • skeletal muscle: 16 nTPM
  • pancreas: 5.2 nTPM
  • tongue: 3.2 nTPM
  • lung: 1.9 nTPM
  • gallbladder: 1.6 nTPM

Single-cell type

  • cardiomyocytes: 586 nCPM
  • alveolar cells type 2: 439 nCPM
  • cholangiocytes: 147 nCPM
  • mast cells: 122 nCPM
  • pancreatic duct cells: 114 nCPM
  • retinal bipolar cells: 98 nCPM

Immune cell

  • T-reg: 14 nTPM
  • naive B-cell: 7.9 nTPM
  • memory B-cell: 7.2 nTPM
  • naive CD4 T-cell: 6.3 nTPM
  • naive CD8 T-cell: 4.9 nTPM
  • memory CD4 T-cell: 2.1 nTPM

Brain region

  • spinal cord: 6.1 nTPM
  • white matter: 6.1 nTPM
  • medulla oblongata: 5.8 nTPM
  • midbrain: 5.1 nTPM
  • pons: 5.1 nTPM
  • cerebellum: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
-0.04

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC141 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC141 as an antibody target. Whether an autoantibody or antibody against CCDC141 could matter depends on whether native CCDC141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC141. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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