Seroatlas · Human Serome Atlas

CCDC140

Coiled-coil domain-containing protein 140

Also known as: CC140_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MF4
Gene: CCDC140
Canonical length: 163 aa

OverviewNCBI Gene

No narrative summary is available for CCDC140 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q96MF4|CCDC140
     1  MGDECSNPDL LAEPGSSPPW DHGNQRQEAA NESNTRVPRV LKAHLGPETA QPTKRSKRNR
    61  WRRQSCQGPS PARSGQFLGS ADLGLQRGVL KSAARTCLSE ISNSTRASPE SAQSTDPGRA
   121  ARPRTRTLPT PHSFKIGEEA EEMKKKKERK RRKERKKERN FKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC140 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.33

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC140 as an antibody target. Whether an autoantibody or antibody against CCDC140 could matter depends on whether native CCDC140 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC140 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC140 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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