Seroatlas · Human Serome Atlas

CCDC14

Coiled-coil domain-containing protein 14

Also known as: CCD14_HUMAN, DKFZp434L1050, FLJ12892

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49A88
Gene: CCDC14
Ensembl: ENSG00000175455
Chromosome: 3
Canonical length: 953 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Primary cilium,Centriolar satellite,Basal body

OverviewNCBI Gene

Involved in protein localization to centrosome. Located in centriolar satellite and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q49A88|CCDC14
     1  MKRGIRRDPF RKRKLGGRAK KVREPTAVNS FYREASLPSV WASLRRREMV RSGARPGQVL
    61  SSGRHTGPAK LTNGKKATYL RKIPRFNADS GYSIHSDSES QAETVHGLDG CASLLRDILR
   121  NEDSGSETAY LENRSNSRPL ESKRYGSKKK RHEKHTIPLV VQKETSSSDN KKQIPNEASA
   181  RSERDTSDLE QNWSLQDHYR MYSPIIYQAL CEHVQTQMSL MNDLTSKNIP NGIPAVPCHA
   241  PSHSESQATP HSSYGLCTST PVWSLQRPPC PPKVHSEVQT DGNSQFASQG KTVSATCTDV
   301  LRNSFNTSPG VPCSLPKTDI SAIPTLQQLG LVNGILPQQG IHKETDLLKC IQTYLSLFRS
   361  HGKETHLDSQ THRSPTQSQP AFLATNEEKC AREQIREATS ERKDLNIHVR DTKTVKDVQK
   421  AKNVNKTAEK VRIIKYLLGE LKALVAEQED SEIQRLITEM EACISVLPTV SGNTDIQVEI
   481  ALAMQPLRSE NAQLRRQLRI LNQQLREQQK TQKPSGAVDC NLELFSLQSL NMSLQNQLEE
   541  SLKSQELLQS KNEELLKVIE NQKDENKKFS SIFKDKDQTI LENKQQYDIE ITRIKIELEE
   601  ALVNVKSSQF KLETAEKENQ ILGITLRQRD AEVTRLRELT RTLQTSMAKL LSDLSVDSAR
   661  CKPGNNLTKS LLNIHDKQLQ HDPAPAHTSI MSYLNKLETN YSFTHSEPLS TIKNEETIEP
   721  DKTYENVLSS RGPQNSNTRG MEEASAPGII SALSKQDSDE GSETMALIED EHNLDNTIYI
   781  PFARSTPEKK SPLSKRLSPQ PQIRAATTQL VSNSGLAVSG KENKLCTPVI CSSSTKEAED
   841  APEKLSRASD MKDTQLLKKI KEAIGKIPAA TKEPEEQTAC HGPSGCLSNS LQVKGNTVCD
   901  GSVFTSDLMS DWSISSFSTF TSRDEQDFRN GLAALDANIA RLQKSLRTGL LEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

retina: 40 nTPM
bone marrow: 35 nTPM
epididymis: 34 nTPM
rectum: 33 nTPM
colon: 28 nTPM
skin: 22 nTPM

Single-cell type

tuft cells: 404 nCPM
early primary spermatocytes: 210 nCPM
bergmann glia: 193 nCPM
pituitary stem cells: 173 nCPM
erythrocyte progenitors: 164 nCPM
megakaryocyte progenitors: 159 nCPM

Immune cell

NK-cell: 2.6 nTPM
T-reg: 2.6 nTPM
plasmacytoid DC: 1.8 nTPM
gdT-cell: 1.4 nTPM
naive CD4 T-cell: 1.4 nTPM
eosinophil: 1.3 nTPM

Brain region

thalamus: 33 nTPM
white matter: 33 nTPM
pons: 32 nTPM
hypothalamus: 31 nTPM
medulla oblongata: 31 nTPM
basal ganglia: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 14
Coiled-coil domain-containing protein 14

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC14 as an antibody target. Whether an autoantibody or antibody against CCDC14 could matter depends on whether native CCDC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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