Seroatlas · Human Serome Atlas

CCDC138

Coiled-coil domain-containing protein 138

Also known as: CC138_HUMAN, FLJ32745

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M89
Gene: CCDC138
Ensembl: ENSG00000163006
Chromosome: 2
Canonical length: 665 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC138 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q96M89|CCDC138
     1  MEPRVVKPPG QDLVVESLKS RYGLGGSCPD EYDFSNFYQS KYKRRTLTSP GDLDIYSGDK
    61  VGSSLKYSDE SKHCRTPLGS LFKHVNVNCL DDELDSFHDL KKQETEEELI ENDYRVSTSK
   121  ITKQSFKEIE KVALPTNTTS SRPRTECCSD AGDSPLKPVS CPKSKASDKR SLLPHQISQI
   181  YDELFQIHLK LQCETAAQQK FAEELQKRER FLLEREQLLF RHENALSKIK GVEEEVLTRF
   241  QIIKEQHDAE VEHLTEVLKE KNKETKRLRS SFDALKELND TLKKQLNEAS EENRKIDIQA
   301  KRVQARLDNL QRKYEFMTIQ RLKGSSHAVH EMKSLKQEKA PVSKTYKVPL NGQVYELLTV
   361  FMDWISDHHL SKVKHEESGM DGKKPQLKFA SQRNDIQEKC VKLLPLMTEQ LQWMPFVNIK
   421  LHEPFVKFIY WSLRQLDAGA QHSTMTSTLR RLGEDIFKGV VTKGIQDNSP QHSVENKPKT
   481  AAFFKSSNLP LRFLSTLIVL KTVTQADYLA QAFDSLCLDL KTEEGKTLFL EYQAVPVILS
   541  HLRISSKGLL SNVIDSLLQM TVESKSLQPF LEACSNSLFF RTCSVLLRAP KLDLQILEKL
   601  SIILQKLSKI KSNKKLFELF TIHLMLQEIQ RTTNPEHAFL CINLNSTLFN LGLTKCNSLV
   661  SSASP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC138 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
thymus: 6 nTPM
lymph node: 4.2 nTPM
fallopian tube: 4 nTPM
tonsil: 3.6 nTPM
bone marrow: 3.3 nTPM

Single-cell type

pdcs: 306 nCPM
respiratory ciliated cells: 260 nCPM
endometrial ciliated cells: 233 nCPM
late primary spermatocytes: 212 nCPM
early spermatids: 205 nCPM
ependymal cells: 200 nCPM

Immune cell

plasmacytoid DC: 4.8 nTPM
naive B-cell: 3.3 nTPM
memory B-cell: 3 nTPM
basophil: 2.6 nTPM
naive CD8 T-cell: 2.6 nTPM
T-reg: 2.4 nTPM

Brain region

cerebellum: 12 nTPM
cerebral cortex: 7.9 nTPM
white matter: 7.8 nTPM
medulla oblongata: 7.3 nTPM
midbrain: 6.7 nTPM
hippocampal formation: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 138
Coiled-coil domain-containing protein 138, C-terminal domain
Coiled-coil-domain-containing protein 138, coiled-coil
Coiled-coil domain-containing protein 138, C-terminal domain
Coiled-coil-domain-containing protein 138, coiled-coil

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC138 as an antibody target. Whether an autoantibody or antibody against CCDC138 could matter depends on whether native CCDC138 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC138 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC138 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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