Seroatlas · Human Serome Atlas

CCDC13

Coiled-coil domain-containing protein 13

Also known as: CCD13_HUMAN, FLJ25467

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYE1
Gene
CCDC13
Ensembl
ENSG00000244607
Chromosome
3
Canonical length
715 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

Acts upstream of or within DNA damage response; cytoplasmic microtubule organization; and non-motile cilium assembly. Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q8IYE1|CCDC13
     1  MAADESSQNT LRLQFKAMQE MQHKRLQKQM EKKREKELSL KSRADDQEEP LEVSDGLSLL
    61  HAGEPNSKNS FEKRVLEDEI EHLRNELRET VDENGRLYKL LKERDFEIKH LKKKIEEDRF
   121  AFTGTAGVAG DVVATKIVEL SKKNRLLMAE SEGAKTRVKQ LTNRIQELER ELQTALTRLS
   181  AKGATDAGAK PPRAQMGDRA LLETPEVKAL QDRLVATNLK MSDLRNQIQS VKQELRMAQK
   241  VLAREVGEDI NVQQLLSSPG TWRGRAQQIL VLQSKVQELE KQLGQARSQS AGTASDELSV
   301  YPDPRKLSAQ EKNLLRIRSL EREKQEGLEK LASERDVLQR ELEELKKKFE GMRSRNKLLS
   361  SEMKTLKSQM GTLVEKGRHD DELIDALMDQ LKQLQEILGS LSLQEEKTRV SQHHLDQQLN
   421  SEAQRSNSLV AQLQAMVAER EAKVRQLEME IGQLNVHYLR NKGVGEGSSG REVSPAYTQF
   481  LEDPGLTKSP ASAGDHVGRL GSSRSVTSLG HTLVESALTR PSLPSPHRTS PRFSDSPEQK
   541  GWQAQVSEIK ALWQAAEVER DRLTEFVTVL QKRVEESNSK LLESERKLQE ERHRTVVLEQ
   601  HLEKIRLEPG KASASQRAAP RTKTGLPTSN NRHNPTGSEK KDPSFAQLSD VPVESQMEEL
   661  TTRLAIQVEE NEMLKAALGS ALRGKEEDFR MYHEILGQVK SVFLQALRQQ KTGKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • retina: 4 nTPM
  • testis: 2.9 nTPM
  • fallopian tube: 2.7 nTPM
  • choroid plexus: 0.9 nTPM
  • spinal cord: 0.9 nTPM
  • hippocampal formation: 0.8 nTPM

Single-cell type

  • ependymal cells: 69 nCPM
  • choroid plexus epithelial cells: 20 nCPM
  • epididymal efferent duct ciliated cells: 13 nCPM
  • fallopian tube ciliated cells: 7.9 nCPM
  • endometrial ciliated cells: 7.7 nCPM
  • loop of henle epithelial cells: 7.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 5 nTPM
  • white matter: 4.2 nTPM
  • midbrain: 3.9 nTPM
  • medulla oblongata: 3.8 nTPM
  • basal ganglia: 3.3 nTPM
  • cerebral cortex: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 13

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC13 as an antibody target. Whether an autoantibody or antibody against CCDC13 could matter depends on whether native CCDC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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