Seroatlas · Human Serome Atlas

CCDC127

Coiled-coil domain-containing protein 127

Also known as: CC127_HUMAN, FLJ25701

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BQ5
Gene: CCDC127
Ensembl: ENSG00000164366
Chromosome: 5
Canonical length: 260 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q96BQ5|CCDC127
     1  MNNLNDPPNW NIRPNSRADG GDGSRWNYAL LVPMLGLAAF RWIWSRESQK EVEKEREAYR
    61  RRTAAFQQDL EAKYHAMISE NRRAVAQLSL ELEKEQNRTA SYREALISQG RKLVEEKKLL
   121  EQERAQVMQE KRQVQPLRSA YLSCLQREEN WQRRARLLLK EFEAVLTERQ NIYCSLFLPR
   181  SKRLEIEKSL LVRASVDPVA ADLEMAAGLT DIFQHDTYCG DVWNTNKRQN GRLMWLYLKY
   241  WELVVELKKF KRVEEAILEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC127 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 29 nTPM
retina: 21 nTPM
thyroid gland: 14 nTPM
skeletal muscle: 12 nTPM
heart muscle: 10 nTPM
cerebral cortex: 9.3 nTPM

Single-cell type

esophageal apical cells: 94 nCPM
late primary spermatocytes: 55 nCPM
cytotrophoblasts: 38 nCPM
extravillous trophoblasts: 37 nCPM
syncytiotrophoblasts: 37 nCPM
migrating cytotrophoblasts: 34 nCPM

Immune cell

naive CD8 T-cell: 7.2 nTPM
memory B-cell: 6.6 nTPM
memory CD8 T-cell: 6.5 nTPM
naive CD4 T-cell: 6.3 nTPM
NK-cell: 6.3 nTPM
naive B-cell: 6 nTPM

Brain region

pons: 36 nTPM
midbrain: 36 nTPM
choroid plexus: 36 nTPM
hypothalamus: 36 nTPM
cerebral cortex: 35 nTPM
cerebellum: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid homeostasis

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 127

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC127 as an antibody target. Whether an autoantibody or antibody against CCDC127 could matter depends on whether native CCDC127 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC127 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC127 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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