Seroatlas · Human Serome Atlas

CCDC126

Coiled-coil domain-containing protein 126

Also known as: CC126_HUMAN, FLJ23031

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EE4
Gene
CCDC126
Ensembl
ENSG00000169193
Chromosome
7
Canonical length
140 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q96EE4|CCDC126
     1  MFFTISRKNM SQKLSLLLLV FGLIWGLMLL HYTFQQPRHQ SSVKLREQIL DLSKRYVKAL
    61  AEENKNTVDV ENGASMAGYA DLKRTIAVLL DDILQRLVKL ENKVDYIVVN GSAANTTNGT
   121  SGNLVPVTTN KRTNVSGSIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC126 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • parathyroid gland: 11 nTPM
  • liver: 11 nTPM
  • tongue: 9.3 nTPM
  • thyroid gland: 8.8 nTPM
  • lymph node: 8.3 nTPM

Single-cell type

  • early spermatids: 783 nCPM
  • late spermatids: 762 nCPM
  • late primary spermatocytes: 254 nCPM
  • neutrophil progenitors: 134 nCPM
  • neutrophils: 116 nCPM
  • early primary spermatocytes: 87 nCPM

Immune cell

  • basophil: 481 nTPM
  • eosinophil: 87 nTPM
  • neutrophil: 35 nTPM
  • memory B-cell: 21 nTPM
  • naive B-cell: 19 nTPM
  • naive CD4 T-cell: 19 nTPM

Brain region

  • cerebellum: 15 nTPM
  • midbrain: 13 nTPM
  • medulla oblongata: 12 nTPM
  • cerebral cortex: 12 nTPM
  • thalamus: 11 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0.12
gnomAD missense Z
0.56
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC126 as an antibody target. Whether an autoantibody or antibody against CCDC126 could matter depends on whether native CCDC126 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC126 is annotated as secreted, so native CCDC126 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCDC126 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC126. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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