Seroatlas · Human Serome Atlas

CCDC125

Coiled-coil domain-containing protein 125

Also known as: CC125_HUMAN, KENAE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86Z20
Gene
CCDC125
Ensembl
ENSG00000183323
Chromosome
5
Canonical length
511 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Intermediate filaments

OverviewNCBI Gene

Enables identical protein binding activity. Involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>Q86Z20|CCDC125
     1  MSKVARSSSE SDVQLWETEE DDMTEGDLGY GLGRKPGGIY EIEFSHRSRK RSDGKNFSPP
    61  PFPRKGEERN EASFQYSKHK SQQDTFPQVS RISNYRRQSS TVDSNSELSN EELRQCLNET
   121  LEEVEMLKTE LEASQRQLRG KEEALKILQS MAILGKATSH TQAVLQKTME QNRSLEKEIN
   181  ALQWEIEFDH NRFKNIEESW IQKYDRLNCE NAVLKENLKV KTEEIKMLKS DNAVLNQRYL
   241  EALAMLDIKQ QKMAQENMCC DKSGFAEASG LELAVLGACL CHGPGGNPCS CARMAASTRK
   301  LLLQLKQELE ILQKSKEEAY VMADAFRIAF EQQLMRKNDQ ALQLTQMDKM HKKATKWMNW
   361  KHLKEDGFPS PRSKKTFGQR LLGMLPSENS SKRMEDQDSP QEVLKMLIDL LNDKEEALAH
   421  QRKVSYMLAR ALEDKDTASN ENKEKNPIKE NFPFNNPWRK TSEFSVLGDP IHSSVCILNS
   481  VGCICSIQHS QIDPNYRTLK RSHSLPSSII F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC125 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • liver: 12 nTPM
  • bone marrow: 10 nTPM
  • breast: 6.5 nTPM
  • prostate: 6.5 nTPM
  • salivary gland: 6.2 nTPM
  • stomach: 5.5 nTPM

Single-cell type

  • neutrophil progenitors: 74 nCPM
  • distal convoluted tubule cells: 67 nCPM
  • microglia: 63 nCPM
  • choroid plexus epithelial cells: 61 nCPM
  • renal connecting tubule cells: 59 nCPM
  • papillary tip epithelial cells: 58 nCPM

Immune cell

  • eosinophil: 15 nTPM
  • neutrophil: 11 nTPM
  • basophil: 7 nTPM
  • non-classical monocyte: 2.8 nTPM
  • myeloid DC: 1.6 nTPM
  • plasmacytoid DC: 1.3 nTPM

Brain region

  • white matter: 7.8 nTPM
  • medulla oblongata: 7.4 nTPM
  • choroid plexus: 6.6 nTPM
  • midbrain: 6.6 nTPM
  • cerebral cortex: 6.3 nTPM
  • pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 125

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC125 as an antibody target. Whether an autoantibody or antibody against CCDC125 could matter depends on whether native CCDC125 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC125 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC125 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC125. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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