Seroatlas · Human Serome Atlas

CCDC122

Coiled-coil domain-containing protein 122

Also known as: CC122_HUMAN, FLJ31846

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T0U0
Gene: CCDC122
Ensembl: ENSG00000151773
Chromosome: 13
Canonical length: 273 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a protein that contains a coiled-coil domain. Naturally occurring mutations in this gene are associated with leprosy. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q5T0U0|CCDC122
     1  MSDNKERKSQ GFPKEDNQDT SSLADAVEKV AKQQQSQASE IEKNKKVLFN LKNELHELEK
    61  EIAAISAETK ETERQIYQQD SAIENTKLHC DSLETQIKSL HSENVKLKFD IETAQEDFEE
   121  HMIKYNAYYA KIKAHKNSLG EVESKWSFMT ELHEKRDFVK KLKTMKEELM QDLQNPGGNR
   181  ITQVQEDITN LKDKIITVKE SIIEKTCFLE EEKKTHEKLR KEIEVQHKRY DAILKRLHCQ
   241  VNKLQSNRRQ WQWNIQQLEK TAAELRKCIG MQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC122 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

ovary: 5.1 nTPM
epididymis: 5 nTPM
prostate: 4.6 nTPM
thyroid gland: 4.6 nTPM
heart muscle: 4.3 nTPM
fallopian tube: 4.1 nTPM

Single-cell type

oligodendrocytes: 129 nCPM
sertoli cells: 114 nCPM
early primary spermatocytes: 93 nCPM
podocytes: 83 nCPM
loop of henle epithelial cells: 66 nCPM
prostatic glandular cells: 57 nCPM

Immune cell

basophil: 3.3 nTPM
neutrophil: 1.4 nTPM
NK-cell: 1.4 nTPM
naive B-cell: 1.3 nTPM
plasmacytoid DC: 1.2 nTPM
non-classical monocyte: 1.1 nTPM

Brain region

white matter: 11 nTPM
basal ganglia: 7.2 nTPM
pons: 6.6 nTPM
medulla oblongata: 6.5 nTPM
midbrain: 5.9 nTPM
thalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC122 as an antibody target. Whether an autoantibody or antibody against CCDC122 could matter depends on whether native CCDC122 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC122 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC122 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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