Seroatlas · Human Serome Atlas

CCDC121

Coiled-coil domain-containing protein 121

Also known as: CC121_HUMAN, FLJ13646, FLJ43364

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUS5
Gene: CCDC121
Ensembl: ENSG00000176714
Chromosome: 2
Canonical length: 278 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC121 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q6ZUS5|CCDC121
     1  MTDLNKHIKQ AQTQRKQLLE ESRELHREKL LVQAENRFFL EYLTNKTEEY TEQPEKVWNS
    61  YLQKSGEIER RRQESASRYA EQISVLKTAL LQKENIQSSL KRKLQAMRDI AILKEKQEKE
   121  IQTLQEETKK VQAETASKTR EVQAQLLQEK RLLEKQLSEP DRRLLGKRKR RELNMKAQAL
   181  KLAAKRFIFE YSCGINRENQ QFKKELLQLI EQAQKLTATQ SHLENRKQQL QQEQWYLESL
   241  IQARQRLQGS HNQCLNRQDV PKTTPSLPQG TKSRINPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC121 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
ovary: 9 nTPM
parathyroid gland: 7.3 nTPM
fallopian tube: 6.7 nTPM
retina: 6.7 nTPM
thyroid gland: 6.7 nTPM

Single-cell type

early spermatids: 246 nCPM
late primary spermatocytes: 93 nCPM
late spermatids: 46 nCPM
fallopian tube ciliated cells: 28 nCPM
respiratory ciliated cells: 27 nCPM
early primary spermatocytes: 22 nCPM

Immune cell

eosinophil: 11 nTPM
neutrophil: 4.2 nTPM
non-classical monocyte: 3.4 nTPM
intermediate monocyte: 2.9 nTPM
memory B-cell: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM

Brain region

thalamus: 17 nTPM
medulla oblongata: 16 nTPM
white matter: 14 nTPM
midbrain: 13 nTPM
cerebellum: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.73
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC121 as an antibody target. Whether an autoantibody or antibody against CCDC121 could matter depends on whether native CCDC121 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC121 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC121 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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