Seroatlas · Human Serome Atlas

CCDC116

Coiled-coil domain-containing protein 116

Also known as: CC116_HUMAN, FLJ36046

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYX3
Gene: CCDC116
Ensembl: ENSG00000161180
Chromosome: 22
Canonical length: 613 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in centrosome. Implicated in lung cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q8IYX3|CCDC116
     1  MARCRHHSGY LADDEASHSM CSARVQLPKK PLVPEMRPAC KPGRVPHPPS TCGSSALQGQ
    61  RRNKRHPQPF GHFLDFLTES QVLDSLETVV EKATERMAAM KTEAGVPLVE VQDPVEVPSG
   121  GRRAHARPSL STVHRHRVRP TLCTGHPNNY PSSSSSMSNC HSSLMAGCLG SHSRDSDLGA
   181  QGSLPPVRDK LLLEKNLKRL LQLEREGKGL SQSCSQRDSL LWDSLGSQTS FQWTQEQPLS
   241  WFSGLLGSSS GVPEASEPRP GEQEPIFRKR EFNKEIKSLL SQLESLDLPG YCPLREPHRT
   301  LNFLADHRLF PALQSVVSQA VDKLRGAHCR DGRPLFPTSL EPTSDLPPLG SEPAKPTNGG
   361  QPYASPRPTV SSPKMLQRKR KDRGGSPSMS SAQVATRFKL KSPCSSSRFT KKKPLPSISS
   421  KSSMSHFSNR LYEELADFLT QQAASLVIRK YEFEKDLSKQ LGFFSFPITH VLRDLSLGLK
   481  KVKGSRIHLS SETHRSCLLR KLEESKRARQ ASRLSTSHCS TETPSVQQEP ATHTAQDQAT
   541  EPCRSLYTNL PASRQLSPLE PKLYMSACTG MGSSPPKSKD MDNEGRDKAE IEDEDEDEFK
   601  DEDQDEDKDE DGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC116 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
endometrium: 1.3 nTPM
blood vessel: 1.2 nTPM
cervix: 1.2 nTPM
ovary: 1.1 nTPM
colon: 1 nTPM

Single-cell type

late spermatids: 270 nCPM
early spermatids: 257 nCPM
late primary spermatocytes: 117 nCPM
sertoli cells: 2.8 nCPM
peritubular myoid cells: 1.6 nCPM
leydig cells: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2 nTPM
cerebellum: 1.5 nTPM
thalamus: 1.5 nTPM
amygdala: 1.4 nTPM
white matter: 1.4 nTPM
basal ganglia: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

centrosome

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4702
Domain of unknown function (DUF4702)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC116 as an antibody target. Whether an autoantibody or antibody against CCDC116 could matter depends on whether native CCDC116 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC116 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC116 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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