Seroatlas · Human Serome Atlas

CCDC107

Coiled-coil domain-containing protein 107

Also known as: CC107_HUMAN, MGC31967

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV48
Gene: CCDC107
Ensembl: ENSG00000159884
Chromosome: 9
Canonical length: 283 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a membrane protein which contains a coiled-coil domain in the central region. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q8WV48|CCDC107
     1  MAGAVSLLGV VGLLLVSALS GVLGDRANPD LRAHPGNAAH PGSGATEPRR RPPLKDQRER
    61  TRAGSLPLGA LYTAAVAAFV LYKCLQGKDE TAVLHEEASK QQPLQSEQQL AQLTQQLAQT
   121  EQHLNNLMAQ LDPLFERVTT LAGAQQELLN MKLWTIHELL QDSKPDKDME ASEPGEGSGG
   181  ESAGGGDKVS ETGTFLISPH TEASRPLPED FCLKEDEEEI GDSQAWEEPT NWSTETWNLA
   241  TSWEVGRGLR RRCSQAVAKG PSHSLGWEGG TTAEGRLKQS LFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC107 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 171 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 171 nTPM
colon: 112 nTPM
adipose tissue: 86 nTPM
heart muscle: 86 nTPM
urinary bladder: 78 nTPM
breast: 73 nTPM

Single-cell type

vascular smooth muscle cells: 311 nCPM
smooth muscle cells: 261 nCPM
alveolar cells type 1: 162 nCPM
epididymal principal cells: 159 nCPM
enterocytes: 134 nCPM
breast myoepithelial cells: 133 nCPM

Immune cell

MAIT T-cell: 169 nTPM
T-reg: 141 nTPM
gdT-cell: 129 nTPM
plasmacytoid DC: 124 nTPM
memory CD8 T-cell: 114 nTPM
memory CD4 T-cell: 112 nTPM

Brain region

thalamus: 21 nTPM
cerebellum: 21 nTPM
pons: 18 nTPM
choroid plexus: 18 nTPM
midbrain: 18 nTPM
cerebral cortex: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 107

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC107 as an antibody target. Whether an autoantibody or antibody against CCDC107 could matter depends on whether native CCDC107 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC107 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC107 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...