CASTOR3P
Putative protein CASTOR3P
Also known as: CAST3_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for CASTOR3P in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
163 residues, UniProt reviewed canonical sequence.
>Q8NAP1|CASTOR3P
1 MSCRGRGAGG RWNSTSWSTG CKLPASPRRV SRCSPTGLIK LAFLFSKTRC KFFSLTETPE
61 DYTIIVDEEG FLELPSSEHL SVADATWLAL NVVSGGGSFS SSQPIGMTKI AKSVIAPLAD
121 QNISVFMLST YQTDFILVLK RDLPFVTHTL SSEFTILWSV ARLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CASTOR3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CASTOR3P as an antibody target. Whether an autoantibody or antibody against CASTOR3P could matter depends on whether native CASTOR3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CASTOR3P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CASTOR3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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