Seroatlas · Human Serome Atlas

CASP12

Inactive caspase-12

Also known as: CASPC_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXS9
Gene: CASP12
Canonical length: 341 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CASP12 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q6UXS9|CASP12
     1  MADEKPSNGV LVHMVKLLIK TFLDGIFDDL MENNVLNTDE IHLIGKCLKF VVSNAENLVD
    61  DITETAQIAG KIFREHLWNS KKQLSSDISS DGEREANMPG LNIRNKEFNY LHNRNGSELD
   121  LLGMRDLLEN LGYSVVIKEN LTAQEMETAL RQFAAHPEHQ SSDSTFLVFM SHSILNGICG
   181  TKHWDQEPDV LHDDTIFEIF NNRNCQSLKD KPKVIIMQAC RGNGAGIVWF TTDSGKASAD
   241  THGRLLQGNI CNDAVTKAHV EKDFIAFKSS TPHNVSWRHE TNGSVFISQI IYYFREYSWS
   301  HHLEEIFQKV QHSFETPNIL TQLPTIERLS MTRYFYLFPG N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CASP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

ovary: 7.4 nTPM
endometrium: 4.3 nTPM
lung: 2.9 nTPM
smooth muscle: 2.6 nTPM
gallbladder: 2.3 nTPM
epididymis: 2.2 nTPM

Single-cell type

lymphatic endothelial cells: 22 nCPM
cardiomyocytes: 18 nCPM
vascular endothelial cells: 8.4 nCPM
ovarian stromal cells: 4.8 nCPM
fibro-adipogenic progenitors: 4.3 nCPM
adipocytes: 4 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
T-reg: 0.2 nTPM
gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 12 nTPM
cerebral cortex: 1.7 nTPM
hippocampal formation: 1.7 nTPM
pons: 1.7 nTPM
thalamus: 1.3 nTPM
midbrain: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 1.26

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type peptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CASP12 as an antibody target. Whether an autoantibody or antibody against CASP12 could matter depends on whether native CASP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CASP12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CASP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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