Seroatlas · Human Serome Atlas

CASC2

Protein CASC2, isoform 3

Also known as: CSC2A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6XLA1
Gene: CASC2
Canonical length: 102 aa

OverviewNCBI Gene

No narrative summary is available for CASC2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>Q6XLA1|CASC2
     1  MTQEKMYPHL FSERCANQHQ HRTAEEKKYV SEKQLIHWRC EEPSAHHNSI DIKRMKHFGS
    61  ALRLRQTFHL DTADHPCVIT MNPALPWKLE GSNSTSTLPL PA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CASC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CASC2 as an antibody target. Whether an autoantibody or antibody against CASC2 could matter depends on whether native CASC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CASC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CASC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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