Seroatlas · Human Serome Atlas

CARMIL3

Capping protein, Arp2/3 and myosin-I linker protein 3

Also known as: BC008134, C14orf121, CARL3_HUMAN, crml-1, LRRC16B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8ND23
Gene
CARMIL3
Ensembl
ENSG00000186648
Chromosome
14
Canonical length
1372 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cell migration and regulation of Arp2/3 complex-mediated actin nucleation. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1372 residues, UniProt reviewed canonical sequence.

>Q8ND23|CARMIL3
     1  MAKPSVELTR ELQDSIRRCL SQGAVLQQHH VKLETKPKKF EDRVLALTSW RLHLFLLKVP
    61  AKVESSFNVL EIRAFNTLSQ NQILVETERG MVSMRLPSAE SVDQVTRHVS SALSKVCPGP
   121  GCLIRRGNAD TPEGPRDTSP NSETSTSTTH SVCGGFSETY AALCDYNGLH CREEVQWDVD
   181  TIYHAEDNRE FNLLDFSHLE SRDLALMVAA LAYNQWFTKL YCKDLRLGSE VLEQVLHTLS
   241  KSGSLEELVL DNAGLKTDFV QKLAGVFGEN GSCVLHALTL SHNPIEDKGF LSLSQQLLCF
   301  PSGLTKLCLA KTAISPRGLQ ALGQTFGANP AFASSLRYLD LSKNPGLLAT DEANALYSFL
   361  AQPNALVHLD LSGTDCVIDL LLGALLHGCC SHLTYLNLAR NSCSHRKGRE APPAFKQFFS
   421  SAYTLSHVNL SATKLPLEAL RALLQGLSLN SHLSDLHLDL SSCELRSAGA QALQEQLGAV
   481  TCVGSLDLSD NGFDSDLLTL VPALGKNKSL KHLFLGKNFN VKAKTLEEIL HKLVQLIQEE
   541  DCSLQSLSVA DSRLKLRTSI LINALGSNTC LAKVDLSGNG MEDIGAKMLS KALQINSSLR
   601  TILWDRNNTS ALGFLDIARA LESNHTLRFM SFPVSDISQA YRSAPERTED VWQKIQWCLV
   661  RNNHSQTCPQ EQAFRLQQGL VTSSAEQMLQ RLCGRVQEEV RALRLCPLEP VQDELLYARD
   721  LIKDAKNSRA LFPSLYELGH VLANDGPVRQ RLESVASEVS KAVDKELQVI LESMVSLTQE
   781  LCPVAMRVAE GHNKMLSNVA ERVTVPRNFI RGALLEQAGQ DIQNKLDEVK LSVVTYLTSS
   841  IVDEILQELY HSHKSLARHL TQLRTLSDPP GCPGQGQDLS SRGRGRNHDH EETTDDELGT
   901  NIDTMAIKKQ KRCRKIRPVS AFISGSPQDM ESQLGNLGIP PGWFSGLGGS QPTASGSWEG
   961  LSELPTHGYK LRHQTQGRPR PPRTTPPGPG RPSMPAPGTR QENGMATRLD EGLEDFFSRR
  1021  VLEESSSYPR TLRTVRPGLS EAPLPPLQKK RRRGLFHFRR PRSFKGDRGP GSPTTGLLLP
  1081  PPPPPPPTQE SPPSPDPPSL GNNSSPCWSP EEESSLLPGF GGGRGPSFRR KMGTEGSEPG
  1141  EGGPAPGTAQ QPRVHGVALP GLERAKGWSF DGKREGPGPD QEGSTQAWQK RRSSDDAGPG
  1201  SWKPPPPPQS TKPSFSAMRR AEATWHIAEE SAPNHSCQSP SPASQDGEEE KEGTLFPERT
  1261  LPARNAKLQD PALAPWPPKP VAVPRGRQPP QEPGVREEAE AGDAAPGVNK PRLRLSSQQD
  1321  QEEPEVQGPP DPGRRTAPLK PKRTRRAQSC DKLEPDRRRP PDPTGTSEPG TD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CARMIL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 22 nTPM
  • pituitary gland: 7.7 nTPM
  • hypothalamus: 4.6 nTPM
  • skin: 3.7 nTPM
  • cerebral cortex: 3.5 nTPM
  • hippocampal formation: 3 nTPM

Single-cell type

  • brain inhibitory neurons: 14 nCPM
  • brain excitatory neurons: 12 nCPM
  • other brain neurons: 12 nCPM
  • astrocytes: 9.4 nCPM
  • oligodendrocyte progenitor cells: 7.1 nCPM
  • bergmann glia: 4.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 9.9 nTPM
  • cerebral cortex: 6.6 nTPM
  • pons: 6.6 nTPM
  • basal ganglia: 6.5 nTPM
  • thalamus: 6.3 nTPM
  • hypothalamus: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CARMIL3 as an antibody target. Whether an autoantibody or antibody against CARMIL3 could matter depends on whether native CARMIL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CARMIL3 is annotated at the cell surface, where native CARMIL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CARMIL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CARMIL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...