CARD6

Protein identityUniProt · HPA

UniProt accession

Q9BX69

Gene

CARD6

Ensembl

ENSG00000132357

Chromosome

5

Canonical length

1037 aa

Protein class

Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1037 residues, UniProt reviewed canonical sequence.

>Q9BX69|CARD6
     1  MATESTPSEI IERERKKLLE ILQHDPDSIL DTLTSRRLIS EEEYETLENV TDLLKKSRKL
    61  LILVQKKGEA TCQHFLKCLF STFPQSAAIC GLRHEVLKHE NTVPPQSMGA SSNSEDAFSP
   121  GIKQPEAPEI TVFFSEKEHL DLETSEFFRD KKTSYRETAL SARKNEKEYD TPEVTLSYSV
   181  EKVGCEVPAT ITYIKDGQRY EELDDSLYLG KEEYLGSVDT PEDAEATVEE EVYDDPEHVG
   241  YDGEEDFENS ETTEFSGEEP SYEGSETSLS LEEEQEKSIE ERKKVFKDVL LCLNMDRSRK
   301  VLPDFVKQFS LDRGCKWTPE SPGDLAWNFL MKVQARDVTA RDSILSHKVL DEDSKEDLLA
   361  GVENLEIRDI QTINPLDVLC ATMLCSDSSL QRQVMSNMYQ CQFALPLLLP DAENNKSILM
   421  LGAMKDIVKK QSTQFSGGPT EDTEKFLTLM KMPVISFVRL GYCSFSKSRI LNTLLSPAQL
   481  KLHKIFLHQD LPLLVLPRQI SDGLVEITWC FPDSDDRKEN PFFQKPVALA NLRGNLESFW
   541  TQFGFLMEVS SAVFFFTDCL GEKEWDLLMF LGEAAIERCY FVLSSQARES EEAQIFQRIL
   601  NLKPAQLLFW ERGDAGDRRK NMEGLQAALQ EVMFSSCLRC VSVEDMAALA RELGIQVDED
   661  FENTQRIQVS SGENMAGTAE GEGQQRHSQL KSSSKSQALM PIQEPGTQCE LSQNLQNLYG
   721  TPVFRPVLEN SWLFPTRIGG NFNHVSLKAS WVMGRPFGSE QRPKWFHPLP FQNAGAQGRG
   781  KSFGIQSFHP QIFYSGERFM KFSRVARGCH SNGTFGRLPR PICQHVQACP ERPQMMGTLE
   841  RSRAVASKIG HSYSLDSQPA RAVGKPWPQQ ACTRVTELTE ATGKLIRTSH IGKPHPQSFQ
   901  PAAATQKLRP ASQQGVQMKT QGGASNPALQ IGSHPMCKSS QFKSDQSNPS TVKHSQPKPF
   961  HSVPSQPKSS QTKSCQSQPS QTKPSPCKST QPKPSQPWPP QSKPSQPRPP QPKSSSTNPS
  1021  QAKAHHSKAG QKRGGKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CARD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.26

gnomAD pLI

0

gnomAD missense Z

-0.41

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• regulation of apoptotic process

Protein domainsUniProt · Pfam · InterPro

• CARD domain
• Death-like domain superfamily
• Apoptosis Repressor CARD Domain-Containing Protein
• Up-regulator of cell proliferation-like domain
• Caspase recruitment domain
• Up-regulator of cell proliferation-like domain

KeywordsUniProt

• Acetylation
• Apoptosis
• Phosphoprotein