CARD17P
Putative caspase recruitment domain-containing protein 17P
Also known as: CAR17_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for CARD17P in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>Q5XLA6|CARD17P
1 MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV MDKARALLDS
61 VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT TQDSQIVLPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CARD17P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to lipopolysaccharide
- negative regulation of interleukin-1 beta production
- proteolysis
- regulation of apoptotic process
Molecular functions
- caspase binding
- cysteine-type endopeptidase activity
- cysteine-type endopeptidase inhibitor activity
- identical protein binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CARD17P as an antibody target. Whether an autoantibody or antibody against CARD17P could matter depends on whether native CARD17P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CARD17P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CARD17P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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