Seroatlas · Human Serome Atlas

CAPSL

Calcyphosin-like protein

Also known as: CAPSL_HUMAN, MGC26610

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWF8
Gene: CAPSL
Ensembl: ENSG00000152611
Chromosome: 5
Canonical length: 208 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Microtubules,Cytokinetic bridge,Primary cilium

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q8WWF8|CAPSL
     1  MAGTARHDRE MAIQAKKKLT TATDPIERLR LQCLARGSAG IKGLGRVFRI MDDDNNRTLD
    61  FKEFMKGLND YAVVMEKEEV EELFRRFDKD GNGTIDFNEF LLTLRPPMSR ARKEVIMQAF
   121  RKLDKTGDGV ITIEDLREVY NAKHHPKYQN GEWSEEQVFR KFLDNFDSPY DKDGLVTPEE
   181  FMNYYAGVSA SIDTDVYFII MMRTAWKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPSL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 104 nTPM
choroid plexus: 86 nTPM
pituitary gland: 13 nTPM
testis: 9.4 nTPM
epididymis: 8 nTPM
hippocampal formation: 7.2 nTPM

Single-cell type

fallopian tube ciliated cells: 852 nCPM
respiratory ciliated cells: 772 nCPM
epididymal efferent duct ciliated cells: 536 nCPM
endometrial ciliated cells: 409 nCPM
late spermatids: 208 nCPM
early spermatids: 150 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 52 nTPM
medulla oblongata: 20 nTPM
midbrain: 20 nTPM
spinal cord: 16 nTPM
white matter: 13 nTPM
hypothalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.49
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPSL as an antibody target. Whether an autoantibody or antibody against CAPSL could matter depends on whether native CAPSL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPSL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPSL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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